INT295848

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.63
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Srpk1) chromosome segregation (Srpk1) mRNA processing (Srpk1)
nucleus (Srpk1) kinase activity (Srpk1) cytoplasm (Srpk1)
Anatomy Link Frequency
eye 1
proximal 1
Srpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.68 Very High Very High Very High
agonist 4 96.60 Very High Very High Very High
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 4 91.16 High High
Leukemia 4 87.28 High High
Retinal Neovascularization 12 74.72 Quite High
Apoptosis 4 73.64 Quite High
Cancer 28 68.84 Quite High
Lung Cancer 4 37.76 Quite Low
Targeted Disruption 4 36.40 Quite Low
Sarcoma 4 34.68 Quite Low
Diabetic Retinopathy 20 32.72 Quite Low
Age-related Macular Degeneration 4 29.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitor of SRPK1/2 kinase, SRPIN340 prevents the down-regulation of the VEGFxxxb isoforms.
Negative_regulation (inhibitor) of SRPK1
1) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.45 Pain Relevance 0
Thus these findings indicate that SRPK1 inhibitors may be potentially anti-angiogenic, and to that end we set out to investigate this in a model of angiogenesis in the eye.
Negative_regulation (inhibitors) of SRPK1 in eye
2) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.11 Pain Relevance 0
This down-regulation of DSS and increased PSS was blocked by protein kinase C inhibition and SRPK1/2 inhibition.
Negative_regulation (inhibition) of SRPK1 associated with kinase c
3) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0.07 Pain Relevance 0.05
We have shown that the IGF-1-mediated increase in VEGF isoforms using the proximal splice site is inhibited by blocking PKC and SRPK1/2, and that this can be overcome by the use of a PKC inhibitor or mimicked by a PKC agonist or overexpression of SRPK1.
Negative_regulation (blocking) of SRPK1 in proximal associated with agonist
4) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.05

General Comments

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