INT295850

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.23
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ccna1) mitosis (Ccna1) cytoskeleton (Ccna1)
nucleus (Ccna1) cell cycle (Ccna1) cell division (Ccna1)
Ccna1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 2 99.42 Very High Very High Very High
Leukemia 2 95.12 Very High Very High Very High
Apoptosis 2 90.04 High High
Cancer 14 85.24 High High
Lung Cancer 2 54.16 Quite High
Targeted Disruption 2 52.80 Quite High
Sarcoma 2 51.08 Quite High
Skin Cancer 4 42.92 Quite Low
Breast Cancer 2 40.96 Quite Low
Colon Cancer 4 40.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SRPK2 is able to bind and phosphorylate acinus, an SR protein, and moves it from nuclear speckles to the nucleoplasm, resulting in the activation of cyclin A1 (52).
Positive_regulation (activation) of cyclin A1
1) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.73 Pain Relevance 0
SRPK2 and acinus were also overexpressed in human acute myelogenous leukemia patients and correlate with elevated cyclin A1 expression levels (52).
Positive_regulation (elevated) of cyclin A1 associated with acute myeloid leukemia
2) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.49 Pain Relevance 0

General Comments

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