INT295851

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.72
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Srpk1) chromosome segregation (Srpk1) mRNA processing (Srpk1)
nucleus (Srpk1) kinase activity (Srpk1) cytoplasm (Srpk1)
Anatomy Link Frequency
Mouse 1
proximal 1
epithelial cells 1
Srpk1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 6 99.92 Very High Very High Very High
anesthesia 6 5.00 Very Low Very Low Very Low
Kinase C 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 42 98.76 Very High Very High Very High
Retinal Neovascularization 18 97.80 Very High Very High Very High
Apoptosis 6 81.76 Quite High
Acute Myeloid Leukemia 6 81.52 Quite High
Leukemia 6 77.64 Quite High
Hypoxia 12 74.88 Quite High
Lung Cancer 6 74.36 Quite High
Targeted Disruption 6 73.00 Quite High
Sarcoma 6 71.28 Quite High
Skin Cancer 12 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have shown that the IGF-1-mediated increase in VEGF isoforms using the proximal splice site is inhibited by blocking PKC and SRPK1/2, and that this can be overcome by the use of a PKC inhibitor or mimicked by a PKC agonist or overexpression of SRPK1.
Gene_expression (overexpression) of SRPK1 in proximal associated with agonist
1) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.05
Fig. 3D shows that overexpression of SRPK1, but not SRPK2, resulted in reduced distal splice site selection and hence reduced overall VEGF levels.
Gene_expression (overexpression) of SRPK1
2) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
SRPK1 seems to be a relatively new target for future cancer therapies but is receiving more attention recently as higher expression of SRPK1 has been observed in breast and colonic tumors, and its increased expression is associated with the grade of a tumor (50).
Gene_expression (expression) of SRPK1 associated with cancer
3) Confidence 0.46 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 1.08 Pain Relevance 0
SRPK1/2 Inhibition Inhibits Angiogenesis in a Mouse Model of Retinal Neovascularization
Gene_expression (/) of SRPK1 in Mouse associated with retinal neovascularization
4) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.25 Pain Relevance 0
To confirm the involvement of SRPK1 or SRPK2 in the terminal splice site choice, epithelial cells were transfected with expression vectors to overexpress SRPK1 and SRPK2.
Gene_expression (overexpress) of SRPK1 in epithelial cells
5) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0
These results indicate that an overactivity of SRPK1 can cause phosphorylation of ASF/SF2.
Gene_expression (overactivity) of SRPK1
6) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.39 Pain Relevance 0

General Comments

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