INT295864

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RNPS1) nucleoplasm (RNPS1) RNA binding (RNPS1)
nucleus (RNPS1) cytoplasm (RNPS1)
Anatomy Link Frequency
epithelial cells 1
RNPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 77.28 Quite High
agonist 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
isoflurane 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 94.40 High High
Cancer 21 89.60 High High
Leukemia 3 87.36 High High
Acute Myeloid Leukemia 3 81.04 Quite High
Diabetic Retinopathy 15 61.12 Quite High
Lung Cancer 3 58.52 Quite High
Targeted Disruption 3 57.16 Quite High
Sarcoma 3 55.44 Quite High
Retinal Neovascularization 9 48.00 Quite Low
Skin Cancer 6 47.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the mechanism by which the pro-angiogenic splice site choice is mediated, we investigated the effect of inhibition of ASF/SF2 phosphorylation by SR protein kinases (SRPK1/2) on splice site choice in epithelial cells and in in vivo angiogenesis models.
Phosphorylation (phosphorylation) of SR protein in epithelial cells
1) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2820781 Disease Relevance 0 Pain Relevance 0.04
To investigate the inhibitory effect of IGF-1 on VEGFxxxb mRNA and protein synthesis, pharmacological inhibitors and IGF-1 with PKC-BIMI (Calbiochem), and SRPK1/2 (SR protein kinases 1 and 2)-SRPIN340 (SR protein phosphorylation inhibitor 340) (17) were used. 24 h before treatment, cultured medium was replaced with serum-free RPMI 1640 medium (Sigma) containing 1% ITS (Sigma) and 0.5% penicillin-streptomycin (Sigma).
Phosphorylation (phosphorylation) of SR protein
2) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.06 Pain Relevance 0
SRPK2 is able to bind and phosphorylate acinus, an SR protein, and moves it from nuclear speckles to the nucleoplasm, resulting in the activation of cyclin A1 (52).
Phosphorylation (phosphorylate) of SR protein
3) Confidence 0.02 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2820781 Disease Relevance 0.75 Pain Relevance 0

General Comments

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