INT295922

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.19
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Accn2)
Accn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ASIC 162 100.00 Very High Very High Very High
ischemia 162 92.68 High High
tolerance 21 80.32 Quite High
Pyramidal cell 15 76.68 Quite High
Glutamate 3 50.56 Quite High
Hippocampus 18 5.00 Very Low Very Low Very Low
tissue acidosis 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 15 94.64 High High
Death 27 94.08 High High
Cv Unclassified Under Development 156 92.68 High High
Acidosis 30 80.64 Quite High
Necrosis 6 75.76 Quite High
Brain Hemorrhage 9 75.00 Quite High
Injury 12 72.64 Quite High
Stroke 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, RT-PCR and western blot analysis showed the preconditioning followed by an ischemic event significantly increased the ASIC 2a mRNA and protein expression when compared to a single ischemic insult (p < 0.01, Figures 3, 4).
Positive_regulation (increased) of Transcription (expression) of ASIC associated with asic
1) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.92 Pain Relevance 0.53
The increase in ASIC 2a mRNA expression in the hippocampal CA1 region in the preconditioned group (PC + Isch) was maximal at 24 h and persisted even at 72 h.


Positive_regulation (increase) of Transcription (expression) of ASIC associated with asic
2) Confidence 0.14 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820994 Disease Relevance 0.60 Pain Relevance 0.58
RT-PCR and western blot analysis showed that preconditioning prior to an ischemic insult significantly increased ASIC 2a mRNA and protein expression in comparison to the ischemic insult alone (p < 0.01).
Positive_regulation (increased) of Transcription (expression) of ASIC associated with asic
3) Confidence 0.09 Published 2010 Journal International Journal of Molecular Sciences Section Abstract Doc Link PMC2820994 Disease Relevance 0.67 Pain Relevance 0.34

General Comments

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