INT295943

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.66
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MTNR1A) signal transducer activity (MTNR1A)
Anatomy Link Frequency
blood 1
MT2 1
MTNR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 96.32 Very High Very High Very High
antidepressant 2 85.76 High High
gABA 1 75.64 Quite High
Raphe 2 68.00 Quite High
midbrain 1 67.76 Quite High
nud 8 23.52 Low Low
depression 5 5.00 Very Low Very Low Very Low
endometriosis 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 64 99.52 Very High Very High Very High
Disease 83 99.00 Very High Very High Very High
Cancer 11 98.36 Very High Very High Very High
Breast Cancer 17 97.08 Very High Very High Very High
INFLAMMATION 3 96.08 Very High Very High Very High
Ulcers 7 94.36 High High
Stress 8 93.76 High High
Malignant Neoplastic Disease 1 89.84 High High
Sleep Disorders 63 84.48 Quite High
Anxiety Disorder 2 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further, there is loss of expression of AVP and MT1 receptors in the SCN.
Negative_regulation (loss) of MT1
1) Confidence 0.21 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2939436 Disease Relevance 0.50 Pain Relevance 0.11
The re-infection rate was significantly lower in the MT1 and MT2 strategy groups than in the ST1 strategy group (RR?
Negative_regulation (lower) of MT1 in MT2 associated with infection
2) Confidence 0.07 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2821909 Disease Relevance 0.43 Pain Relevance 0
When these animals were given the melatonin rich blood and a melatonin receptor inhibitor, or blood collected during the day, the tumor suppressive effects were eliminated [50].
Negative_regulation (inhibitor) of melatonin receptor in blood associated with cancer
3) Confidence 0.01 Published 2010 Journal International Journal of Endocrinology Section Body Doc Link PMC2834958 Disease Relevance 1.11 Pain Relevance 0
Furthermore, Kato et al. [7] demonstrated the inhibitory action of melatonin on secretion of HCL and pepsin.
Negative_regulation (action) of melatonin
4) Confidence 0.01 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2821302 Disease Relevance 0.62 Pain Relevance 0.14

General Comments

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