INT295974

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.30
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) extracellular space (Fgf23)
Anatomy Link Frequency
fibroblast 2
Fgf23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 6 55.00 Quite High
abdominal pain 2 31.84 Quite Low
colic 2 27.28 Quite Low
Disease Link Frequency Relevance Heat
Kidney Stones 44 99.28 Very High Very High Very High
Hypophosphatemia 22 84.80 Quite High
Rickets 24 83.20 Quite High
Disease 6 78.48 Quite High
Pain 6 55.00 Quite High
Abdominal Pain 2 31.84 Quite Low
Renal Colic 2 27.76 Quite Low
Scoliosis 2 9.04 Low Low
Nephrocalcinosis 6 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The candidate gene region was narrowed to a 1.6 Mb region on chromosome 9q34, and the mutated gene was identified as the SLC34A3, which encodes the type 2c sodium phosphate cotransporter (NPT2c), that, with the NPT2a, is expressed at the apical domain of renal proximal tubular cells and reabsorb phosphate from the glomerular filtrate under the hormonal control of PTH and the fibroblast growth factor 23 (FGF23) [4-7].
Regulation (control) of FGF23 in fibroblast
1) Confidence 0.07 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2821378 Disease Relevance 1.15 Pain Relevance 0.06
The candidate gene region was narrowed to a 1.6 Mb region on chromosome 9q34, and the mutated gene was identified as the SLC34A3, which encodes the type 2c sodium phosphate cotransporter (NPT2c), that, with the NPT2a, is expressed at the apical domain of renal proximal tubular cells and reabsorb phosphate from the glomerular filtrate under the hormonal control of PTH and the fibroblast growth factor 23 (FGF23) [4-7].
Regulation (control) of factor 23 in fibroblast
2) Confidence 0.06 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2821378 Disease Relevance 1.15 Pain Relevance 0.06

General Comments

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