INT29598

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Context Info
Confidence 0.31
First Reported 1982
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.09
Pain Relevance 1.71

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endoplasmic reticulum (Cyp21a1)
Anatomy Link Frequency
brain 1
Cyp21a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 4 100.00 Very High Very High Very High
analgesia 4 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Dynorphin 1 100.00 Very High Very High Very High
Analgesic 2 96.24 Very High Very High Very High
Paracetamol 1 92.24 High High
Intracerebroventricular 1 89.60 High High
opiate 4 82.32 Quite High
Enkephalin 2 77.68 Quite High
Disease Link Frequency Relevance Heat
Toxicity 1 88.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PCP analogs inhibit potently high affinity [3H]PCP-3-OH binding and (+) [3H]SKF 10047 binding, moderately the low affinity binding component of [3H]PCP-3-OH and very weakly (+) [3H]-3-PPP binding. (+)SKF 10047 and cyclazocine are potent to moderate inhibitors of (+) [3H]SKF 10047, high affinity [3H]PCP-3-OH and (+) [3H]-3-PPP binding, but extremely weak inhibitors of low affinity [3H]PCP-3-OH binding.
PCP-3-OH Binding (binding) of
1) Confidence 0.31 Published 1988 Journal Life Sci. Section Abstract Doc Link 2893238 Disease Relevance 0 Pain Relevance 0.07
PCP analogs inhibit potently high affinity [3H]PCP-3-OH binding and (+) [3H]SKF 10047 binding, moderately the low affinity binding component of [3H]PCP-3-OH and very weakly (+) [3H]-3-PPP binding. (+)SKF 10047 and cyclazocine are potent to moderate inhibitors of (+) [3H]SKF 10047, high affinity [3H]PCP-3-OH and (+) [3H]-3-PPP binding, but extremely weak inhibitors of low affinity [3H]PCP-3-OH binding.
PCP-3-OH Binding (binding) of
2) Confidence 0.31 Published 1988 Journal Life Sci. Section Abstract Doc Link 2893238 Disease Relevance 0 Pain Relevance 0.08
The antipsychotic agents display high affinity for (+) [3H]-3-PPP binding sites, moderate affinity for (+) [3H]SKF 10047 sites and have no effect on either the high or low affinity [3H]PCP-3-OH binding.
PCP-3-OH Binding (binding) of
3) Confidence 0.31 Published 1988 Journal Life Sci. Section Abstract Doc Link 2893238 Disease Relevance 0 Pain Relevance 0.06
Additions of ascorbate, menadione, thiol-containing amino acids and glutathione (GSH) led to an increased stability of N-OH-pHAA, reduced the covalent binding of N-OH-pHAA to cellular protein and decreased GSH depletion caused by N-OH-pHAA.
N-OH-pHAA Binding (binding) of
4) Confidence 0.29 Published 1982 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 7113726 Disease Relevance 0.09 Pain Relevance 0.09
CP-OH showed no binding affinity for brain kappa receptors to which dynorphin, an opioid peptide that inhibits morphine analgesia, binds predominantly.
CP-OH Binding (binds) of in brain associated with dynorphin, opioid, analgesia and morphine
5) Confidence 0.10 Published 1988 Journal FEBS Lett. Section Abstract Doc Link 2838332 Disease Relevance 0 Pain Relevance 1.40

General Comments

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