INT2960

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Context Info
Confidence 0.47
First Reported 1975
Last Reported 2009
Negated 6
Speculated 7
Reported most in Abstract
Documents 32
Total Number 40
Disease Relevance 10.32
Pain Relevance 18.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (Dbh) cytoplasm (Dbh)
Anatomy Link Frequency
plasma 8
nucleus accumbens 4
heart 3
CSF 2
brain 2
Dbh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 281 100.00 Very High Very High Very High
Enkephalin 59 100.00 Very High Very High Very High
Nicotine 28 100.00 Very High Very High Very High
Clonidine 27 100.00 Very High Very High Very High
Migraine 26 100.00 Very High Very High Very High
Catecholamine 24 100.00 Very High Very High Very High
monoamine 1 100.00 Very High Very High Very High
fortral 3 99.98 Very High Very High Very High
gABA 43 99.92 Very High Very High Very High
Acupuncture 206 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Migraine Disorders 26 100.00 Very High Very High Very High
Stress 31 99.82 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 3 99.48 Very High Very High Very High
Cv General 4 Under Development 17 99.24 Very High Very High Very High
Ganglion Cysts 13 98.88 Very High Very High Very High
Pain 4 98.80 Very High Very High Very High
Myocardial Infarction 8 98.64 Very High Very High Very High
Hypertension 8 97.56 Very High Very High Very High
Angina 1 97.20 Very High Very High Very High
Injury 8 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dopamine beta-hydroxylase and phenylethanolamine N-methyltransferase promoters were not affected by butyrate treatment.
Neg (not) Regulation (affected) of Dopamine beta-hydroxylase associated with dopamine
1) Confidence 0.47 Published 2003 Journal Pediatr. Res. Section Abstract Doc Link 12508089 Disease Relevance 0.08 Pain Relevance 0.25
The effects of two dopamine-beta-hydroxylase (DBH) inhibitors, FLA-63 and fusaric acid (FA) on feeding behaviour and locomotor activity were examined.
Spec (examined) Regulation (effects) of DBH associated with dopamine and eae
2) Confidence 0.45 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3991764 Disease Relevance 0 Pain Relevance 0.17
The effects of two dopamine-beta-hydroxylase (DBH) inhibitors, FLA-63 and fusaric acid (FA) on feeding behaviour and locomotor activity were examined.
Spec (examined) Regulation (effects) of dopamine-beta-hydroxylase associated with dopamine and eae
3) Confidence 0.45 Published 1985 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 3991764 Disease Relevance 0 Pain Relevance 0.17
The study implicates hormonal involvement in the stress-induced changes in TH, DBH, NPY, and proenkephalin gene expression in sympathetic ganglia.
Regulation (changes) of DBH in sympathetic associated with stress
4) Confidence 0.45 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.61 Pain Relevance 0.28
This study analysed the effects of both seven and 30 days of treatment with clonidine on heart rate, blood pressure (BP), plasma norepinephrine (NE) levels and dopamine-beta-hydroxylase (DBH) activity at rest and after standing in seven patients with essential hypertension.
Spec (analysed) Regulation (effects) of dopamine-beta-hydroxylase in heart associated with dopamine, hypertension and clonidine
5) Confidence 0.44 Published 1983 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6679510 Disease Relevance 0.43 Pain Relevance 0.44
This study analysed the effects of both seven and 30 days of treatment with clonidine on heart rate, blood pressure (BP), plasma norepinephrine (NE) levels and dopamine-beta-hydroxylase (DBH) activity at rest and after standing in seven patients with essential hypertension.
Spec (analysed) Regulation (effects) of DBH in heart associated with dopamine, hypertension and clonidine
6) Confidence 0.44 Published 1983 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6679510 Disease Relevance 0.43 Pain Relevance 0.44
This study was designed to: (1) investigate the effect of drugs which alter central noradrenergic activity on DBH activity in CSF; and (2) compare the effects of these drugs on DBH in CSF and plasma in cats.
Regulation (effects) of DBH in plasma
7) Confidence 0.43 Published 1980 Journal Brain Res. Section Abstract Doc Link 7363084 Disease Relevance 0 Pain Relevance 0.19
The promoter DBH marker, reported associated with migraine in this study, has been shown to affect up to 52% of plasma DBH activity.
Regulation (affect) of DBH in plasma associated with migraine
8) Confidence 0.38 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19219470 Disease Relevance 0.98 Pain Relevance 1.09
TM reduced catecholamine content in brain, adrenals and heart but had no influence on monoamine oxidase or dopamine-beta-hydroxylase.
Neg (no) Regulation (influence) of dopamine-beta-hydroxylase in heart associated with dopamine, catecholamine and monoamine
9) Confidence 0.38 Published 1975 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 1240070 Disease Relevance 0.72 Pain Relevance 0.28
In previous studies, we demonstrated changes in individual patterns of immunoreactivity for growth-associated protein-43, dopamine beta-hydroxylase and substance P that suggest growth and/or changes in expression of neurotransmitter enzymes and peptides in the cord caudal to a transection injury.
Regulation (immunoreactivity) of dopamine beta-hydroxylase associated with neurotransmitter, dopamine, injury and substance p
10) Confidence 0.37 Published 1999 Journal Neuroscience Section Abstract Doc Link 10336136 Disease Relevance 1.02 Pain Relevance 0.59
Effect of variations in pituitary-adrenal activity on dopamine-beta-hydroxylase activity in various regions of rat brain.
Regulation (Effect) of dopamine-beta-hydroxylase in pituitary associated with dopamine
11) Confidence 0.27 Published 1976 Journal Neuroendocrinology Section Title Doc Link 967301 Disease Relevance 0.23 Pain Relevance 0.22
Prolonged cortisol administration failed to alter the mRNA levels of TH, DBH, and NPY in control animals but attenuated the response to stress.
Neg (failed) Regulation (alter) of DBH associated with stress
12) Confidence 0.27 Published 1996 Journal Endocrinology Section Abstract Doc Link 8940389 Disease Relevance 0.58 Pain Relevance 0.31
The promoter DBH marker, reported associated with migraine in this study, has been shown to affect up to 52% of plasma DBH activity.
Regulation (affect) of DBH in plasma associated with migraine
13) Confidence 0.26 Published 2009 Journal Neurogenetics Section Abstract Doc Link 19219470 Disease Relevance 0.90 Pain Relevance 1.07
The effect of clonidine on plasma DBH was strongly dependent on the basal enzyme level.
Regulation (effect) of DBH in plasma associated with clonidine
14) Confidence 0.26 Published 1980 Journal Brain Res. Section Abstract Doc Link 7363084 Disease Relevance 0 Pain Relevance 0.29
The data demonstrate an effect of the adrenal glands on brain DBH activity, but it is as yet uncertain whether this effect is mediated by glucocorticoids.
Regulation (effect) of DBH in brain
15) Confidence 0.24 Published 1976 Journal Neuroendocrinology Section Abstract Doc Link 967301 Disease Relevance 0.25 Pain Relevance 0.19
The values of DBH were elevated in both groups on day one.
Regulation (values) of DBH
16) Confidence 0.24 Published 1978 Journal Clin. Chim. Acta Section Abstract Doc Link 729170 Disease Relevance 0.37 Pain Relevance 0.18
Neurosurgery or administration of analgesics and/or sedatives had little effect on the changes in plasma DBH activity in acute SAH.
Regulation (changes) of plasma DBH in plasma associated with analgesic and cva
17) Confidence 0.24 Published 1979 Journal No To Shinkei Section Abstract Doc Link 574016 Disease Relevance 0.74 Pain Relevance 0.35
[Changes in plasma dopamine-beta-hydroxylase activity in patients with acute subarachnoid hemorrhage (author's transl)].
Regulation (Changes) of dopamine-beta-hydroxylase in plasma associated with fortral, dopamine, cv general 4 under development and cva
18) Confidence 0.24 Published 1979 Journal No To Shinkei Section Title Doc Link 574016 Disease Relevance 0.60 Pain Relevance 0.42
Neurosurgery or administration of analgesics and/or sedatives had little effect on the changes in plasma DBH activity in acute SAH.
Neg (little) Regulation (effect) of plasma DBH in plasma associated with analgesic and cva
19) Confidence 0.24 Published 1979 Journal No To Shinkei Section Abstract Doc Link 574016 Disease Relevance 0.74 Pain Relevance 0.35
Patients with multiple signs of sympathetic hyperactivity had significantly higher values for the activity of dopamine beta-hydroxylase on admission.
Regulation (values) of dopamine beta-hydroxylase in sympathetic associated with dopamine and attention deficit hyperactivity disorder
20) Confidence 0.24 Published 1978 Journal Chest Section Abstract Doc Link 738089 Disease Relevance 0.53 Pain Relevance 0.32

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