INT296035

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Context Info
Confidence 0.01
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL21) extracellular space (IL21) extracellular region (IL21)
plasma membrane (IL23R)
IL21 (Homo sapiens)
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 36 64.72 Quite High
Inflammation 32 50.52 Quite High
Multiple sclerosis 1 33.12 Quite Low
Crohn's disease 4 32.16 Quite Low
psoriasis 1 31.48 Quite Low
rheumatoid arthritis 1 31.04 Quite Low
tolerance 13 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 30 50.52 Quite High
Cancer 33 48.00 Quite Low
Communicable Diseases 2 42.72 Quite Low
Disease 22 35.72 Quite Low
Demyelinating Disease 1 33.12 Quite Low
Psoriasis 1 31.48 Quite Low
Rheumatoid Arthritis 2 31.04 Quite Low
Inflammatory Bowel Disease 30 5.00 Very Low Very Low Very Low
Autoimmune Disease 12 5.00 Very Low Very Low Very Low
Colitis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At low concentration, TGF-beta synergizes with IL-6 and IL-21 to promote IL-23R expression, favoring TH17 cell differentiation.
IL-21 Positive_regulation (promote) of Gene_expression (expression) of IL-23R
1) Confidence 0.01 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.05 Pain Relevance 0.08

General Comments

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