INT296054

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Context Info
Confidence 0.33
First Reported 2009
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 17.97
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il22) extracellular region (Il22)
Anatomy Link Frequency
respiratory 3
Th17 cells 2
macrophages 1
colon 1
dendritic cells 1
Il22 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 349 100.00 Very High Very High Very High
Crohn's disease 148 99.80 Very High Very High Very High
Inflammation 351 99.02 Very High Very High Very High
Multiple sclerosis 207 98.92 Very High Very High Very High
psoriasis 223 93.92 High High
chemokine 23 93.60 High High
Spinal cord 2 76.52 Quite High
Inflammatory response 25 67.04 Quite High
Infliximab 21 66.52 Quite High
Inflammatory mediators 15 58.04 Quite High
Disease Link Frequency Relevance Heat
Psoriasis 275 99.84 Very High Very High Very High
Disease 455 99.80 Very High Very High Very High
Acanthosis 4 99.80 Very High Very High Very High
Burns 126 99.68 Very High Very High Very High
Candida Infection 56 99.26 Very High Very High Very High
Inflammatory Bowel Disease 209 99.02 Very High Very High Very High
Myocarditis 6 99.02 Very High Very High Very High
Demyelinating Disease 244 98.92 Very High Very High Very High
INFLAMMATION 365 97.92 Very High Very High Very High
Infection 157 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In UC samples, IL17A (P = 0.0002), IL21 (P = 0.0021), IL22 (P = 0.0003) and IL26 (P = 0.0017) were strongly induced, and IL17F (P = 0.046) was weakly induced, while in colonic CD samples, IL17A (P = 0.0084) and IL22 (P = 0.001) were strongly induced, and IL21 (P = 0.047), IL26 (P = 0.048) and IL17F (P = 0.011) were weakly induced (Figure 2B).
Positive_regulation (induced) of IL22 associated with inflammatory bowel disease and crohn's disease
1) Confidence 0.33 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.53 Pain Relevance 0.53
In UC samples, IL17A (P = 0.0002), IL21 (P = 0.0021), IL22 (P = 0.0003) and IL26 (P = 0.0017) were strongly induced, and IL17F (P = 0.046) was weakly induced, while in colonic CD samples, IL17A (P = 0.0084) and IL22 (P = 0.001) were strongly induced, and IL21 (P = 0.047), IL26 (P = 0.048) and IL17F (P = 0.011) were weakly induced (Figure 2B).
Positive_regulation (induced) of IL22 associated with inflammatory bowel disease and crohn's disease
2) Confidence 0.33 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.48 Pain Relevance 0.51
In ileal CD samples, IL22 (P = 0.0015) was strongly induced, while IL17A (P = 0.013), IL26 (P = 0.029) and IL17F (P = 0.019) were weakly induced, and expression levels of IL21 were similar to those in ileal controls.
Positive_regulation (induced) of IL22 associated with crohn's disease
3) Confidence 0.29 Published 2010 Journal BMC Immunol Section Body Doc Link PMC3016394 Disease Relevance 1.61 Pain Relevance 0.52
As shown in figure 2, burn induced an early myocardial inflammation as evidenced by significantly higher (P < 0.05) levels of IL-17, IL-6 and IL-22 in the burn group as compared to the sham animals.
Positive_regulation (levels) of IL-22 associated with myocarditis, inflammation and burns
4) Confidence 0.28 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC2918605 Disease Relevance 1.41 Pain Relevance 0.14
Cardiac tissue levels of the Th-17 cytokines, IL-6, IL-17 and IL-22 were significantly elevated at 3 hrs after burn as compared to sham levels.
Positive_regulation (elevated) of IL-22 associated with burns and cytokine
5) Confidence 0.26 Published 2010 Journal J Inflamm (Lond) Section Abstract Doc Link PMC2918605 Disease Relevance 1.17 Pain Relevance 0.21
Due to the presence of T cells and sporadic numbers of dendritic cells and macrophages within infiltrates, an increase in the levels of proinflammatory cytokines such as interleukin-17 (IL-17), IL-22, and IL-23 was also detected locally and systemically.
Positive_regulation (increase) of IL-22 in macrophages associated with cytokine
6) Confidence 0.17 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.23 Pain Relevance 0.05
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Positive_regulation (increased) of IL-22 in respiratory associated with psoriasis, disease and infection
7) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.27 Pain Relevance 0.30
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (dependent) of IL-22 in respiratory associated with psoriasis, disease and infection
8) Confidence 0.17 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.25 Pain Relevance 0.30
IL-22 is also increased in psoriatic lesions and in plasma and these levels correlate with disease severity.18 Multiple reports have also implicated the IL-23 dependent IL-22, but not IL-17 production, in protective immunity to infection with gram-negative organisms such as Salmonella enteritidis in the respiratory and digestive epithelium.19–21 Recently, a Th22 cell subpopulation (characterized by the secretion of IL-22 and TNF-?)
Neg (not) Positive_regulation (implicated) of IL-22 in respiratory associated with psoriasis, disease and infection
9) Confidence 0.12 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.26 Pain Relevance 0.30
Another study confirmed that IL-23 is an important cytokine is involved in the development of IL-17 producing Th17 cells.15 These authors showed that IL-22 is preferentially produced by Th17 cells and mediates the acanthosis induced by IL-23.
Positive_regulation (mediates) of IL-22 in Th17 cells associated with acanthosis and cytokine
10) Confidence 0.12 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 1.03 Pain Relevance 0.27
Th17 cells produce IL-17A and IL-17F, which are upregulated in chronic lesions [172, 173], and IL-22 which is also involved in MS pathogenesis.
Positive_regulation (upregulated) of IL-22 in Th17 cells associated with multiple sclerosis
11) Confidence 0.10 Published 2011 Journal Autoimmune Diseases Section Body Doc Link PMC3003960 Disease Relevance 1.48 Pain Relevance 0.41
TH17 associated cytokines (IL-17A, IL-17F, IL-21, IL-22) are elevated in bioptic specimens from IBD inflamed colon and in the sera during active disease.
Positive_regulation (elevated) of IL-22 in colon associated with inflammatory bowel disease, disease and cytokine
12) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 1.50 Pain Relevance 0.31
Due to the presence of T cells and sporadic numbers of dendritic cells and macrophages within infiltrates, an increase in the levels of proinflammatory cytokines such as interleukin-17 (IL-17), IL-22, and IL-23 was also detected locally and systemically.
Positive_regulation (increase) of IL-22 in dendritic cells associated with cytokine
13) Confidence 0.06 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.23 Pain Relevance 0.05
Moreover, PBMCs from a CMC patient were found to produce lower levels of IL-17A and IL-22 in response to C. albicans stimulation compared with cells from a healthy individual.
Positive_regulation (levels) of IL-22 associated with candida infection
14) Confidence 0.05 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.51 Pain Relevance 0.15

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