INT296064

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T-helper cells 2
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 36 100.00 Very High Very High Very High
Inflammation 32 54.72 Quite High
rheumatoid arthritis 1 23.84 Low Low
psoriasis 1 22.08 Low Low
Crohn's disease 4 21.20 Low Low
tolerance 13 19.56 Low Low
Multiple sclerosis 1 19.52 Low Low
adenocard 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 12 56.56 Quite High
INFLAMMATION 30 54.72 Quite High
Disease 22 28.80 Quite Low
Rheumatoid Arthritis 2 23.84 Low Low
Psoriasis 1 22.08 Low Low
Demyelinating Disease 1 19.52 Low Low
Cancer 33 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 30 5.00 Very Low Very Low Very Low
Colitis 8 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RORgammat induces transcription of the genes encoding IL-17 and the related cytokine IL-17F in naive CD4+ T-helper cells and is required for their expression in response to IL-6 and TGF-beta, the cytokines known to induce IL-17.
Positive_regulation (induces) of Transcription (transcription) of CD4 in T-helper cells associated with cytokine
1) Confidence 0.28 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.11 Pain Relevance 0.21

General Comments

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