INT296140

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Chek1) nucleus (Chek1) cell cycle (Chek1)
kinase activity (Chek1) cytoplasm (Chek1)
Chek1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 6 5.00 Very Low Very Low Very Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2 78.72 Quite High
Ovarian Cancer 2 69.92 Quite High
Breast Cancer 8 67.36 Quite High
Genomic Instability 2 61.60 Quite High
Metastasis 2 59.68 Quite High
Neurodegenerative Disease 14 55.92 Quite High
Disease 10 35.36 Quite Low
Microcephaly 12 17.84 Low Low
Syndrome 12 16.60 Low Low
Chromosome Breakage 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in patient cells with MCPH1 truncating mutations no downregulation of BRCA1 and CHK1 was observed [13].
Neg (no) Negative_regulation (downregulation) of CHK1
1) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.34 Pain Relevance 0
More specifically, there was no significant reduction in the expression levels of Chk1, Brca1, Topbp1, Rad51, Ddb2, p73, Apaf1, or caspases which were all described to show reduced expression following MCPH1 knockdowns [34] (Tables S3, S4, S5).
Neg (no) Negative_regulation (reduction) of Chk1
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.11 Pain Relevance 0

General Comments

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