INT296145

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.18
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mcph1) intracellular (Mcph1) molecular_function (Mcph1)
cellular_component (Mcph1) biological_process (Mcph1) cytoplasm (Mcph1)
Mcph1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 12 84.04 Quite High
cerebral cortex 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 24 95.60 Very High Very High Very High
Chromosome Breakage 20 9.36 Low Low
Neurodegenerative Disease 28 5.00 Very Low Very Low Very Low
Microcephaly 24 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Breast Cancer 16 5.00 Very Low Very Low Very Low
Chromosome Aberrations 8 5.00 Very Low Very Low Very Low
Lifespan 8 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low
Dislocations 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First sample pairs (Mcph1gt/gt and control) were matched individually.
Regulation (control) of Mcph1gt
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0.04
Thus, the mouse model should prove useful for the further delineating of the consequences of MCPH1 mutations on patient's health and to unravel the molecular mechanisms which determine microcephalin/BRIT functions.


Spec (determine) Regulation (determine) of microcephalin
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.09 Pain Relevance 0
Evidence comes from the confirmation of the defect in the regulation of chromosome condensation in proliferating cells of the Mcph1gt/gt-mice.
Regulation (regulation) of Mcph1gt
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.10 Pain Relevance 0
The respective Ct-values of the Hprt, and Mcph1 wild type and trap alleles were related to the standard curves.
Regulation (values) of Mcph1
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

General Comments

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