INT296151

Context Info Confidence 0.78 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 13 Disease Relevance 1.33 Pain Relevance 0.19

cytoskeleton (Mcph1) intracellular (Mcph1) molecular_function (Mcph1) cellular_component (Mcph1) biological_process (Mcph1) cytoplasm (Mcph1)

Anatomy Link Frequency liver 1 brain 1 spleen 1 Mcph1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 39 97.20 isoflurane 13 96.88 cerebral cortex 26 5.00 anesthesia 13 5.00

Disease Link Frequency Relevance Heat Breast Cancer 52 99.52 Genomic Instability 13 98.76 Ovarian Cancer 13 98.28 Metastasis 13 97.80 Dislocations 13 94.96 Cancer 13 93.52 Syndrome 78 65.76 Body Weight 13 34.80 Microcephaly 78 24.40 Neurodegenerative Disease 91 21.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The results revealed that in comparison to the low-abundant endogenous control gene Hprt, Mcph1 is expressed at very low levels in all analyzed tissues.

Spec (analyzed) Gene_expression (expressed) of Mcph1

1) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

Generation of the Mcph1 Deficient Mice

Gene_expression (Generation) of Mcph1

2) Confidence 0.78 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

Control and Mcph1gt/gt mice at 15 weeks of age (n?

Gene_expression (Control) of Mcph1gt

3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.09 Pain Relevance 0.03

This may be explained by low expression rates of Mcph1.

Gene_expression (expression) of Mcph1

4) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

5), and homozygous Mcph1gt/gt (n?

Gene_expression (/) of Mcph1gt

5) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0.14

We compared the expression in liver, brain, and spleen of three Mcph1gt/gt animals to three controls by relative quantification.

Gene_expression (expression) of Mcph1gt in spleen

6) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

Thus, our problems detecting the Mcph1 protein can be explained by these very low expression levels.

Gene_expression (detecting) of Mcph1 protein

7) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

Control and Mcph1gt/gt mice at 15 weeks of age (n?

Gene_expression (/) of Mcph1gt

8) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.09 Pain Relevance 0.03

MCPH1 expression was inversely correlated with genomic instability and metastasis.

Gene_expression (expression) of MCPH1 associated with genomic instability and metastasis

9) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.63 Pain Relevance 0

These findings correlate with data obtained by the cloning and expression of chicken Mcph1 [16].

Gene_expression (expression) of Mcph1

10) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.52 Pain Relevance 0

Ct-method using Mcph1-specific primers F1: 5?

Gene_expression (using) of Mcph1

11) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

We compared the expression in liver, brain, and spleen of three Mcph1gt/gt animals to three controls by relative quantification.

Gene_expression (expression) of Mcph1gt in brain

12) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

We compared the expression in liver, brain, and spleen of three Mcph1gt/gt animals to three controls by relative quantification.

Gene_expression (expression) of Mcph1gt in liver

13) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0

General Comments

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