INT296152

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Context Info
Confidence 0.59
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 0.83
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Mcph1) intracellular (Mcph1) molecular_function (Mcph1)
cellular_component (Mcph1) biological_process (Mcph1) cytoplasm (Mcph1)
Anatomy Link Frequency
spleen 2
brain 1
fibroblasts 1
Mcph1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 24 5.00 Very Low Very Low Very Low
cerebral cortex 16 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 56 91.08 High High
Disease 40 84.80 Quite High
Syndrome 48 84.08 Quite High
Osteogenic Sarcomas 8 81.64 Quite High
Chromosome Breakage 40 12.68 Low Low
Body Weight 8 10.08 Low Low
Microcephaly 48 5.00 Very Low Very Low Very Low
Breast Cancer 32 5.00 Very Low Very Low Very Low
Chromosome Aberrations 16 5.00 Very Low Very Low Very Low
Lifespan 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative real time PCR showed that Mcph1 and Mcph1gt were efficiently depleted by >70% (Figure S3).
Negative_regulation (depleted) of Mcph1gt
1) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0
Quantitative real time PCR showed that Mcph1 and Mcph1gt were efficiently depleted by >70% (Figure S3).
Negative_regulation (depleted) of Mcph1
2) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0
In Mcph1gt/gt the mRNA level of wt Mcph1 was reduced to approximately 9%±2.5 in spleen, 19%±3.2 in liver, and 28%±4.3 in brain, indicating that the Mcph1 genetrap mutation results - as expected - in a preferential splicing of exon 11 of the Mcph1-gene to the gene trap vector.
Negative_regulation (reduced) of Mcph1 in spleen
3) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0
We describe here the first mammalian model with misregulated mitotic chromosome condensation due to defective Mcph1 function.
Negative_regulation (defective) of Mcph1
4) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.67 Pain Relevance 0
In Mcph1gt/gt the mRNA level of wt Mcph1 was reduced to approximately 9%±2.5 in spleen, 19%±3.2 in liver, and 28%±4.3 in brain, indicating that the Mcph1 genetrap mutation results - as expected - in a preferential splicing of exon 11 of the Mcph1-gene to the gene trap vector.
Negative_regulation (reduced) of Mcph1gt in spleen
5) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0
We could show that a mutation caused by a gene trap vector results in impaired Mcph1 function.
Negative_regulation (impaired) of Mcph1
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.08 Pain Relevance 0
In wild type tissues the copy numbers of Mcph1 per microgram RNA compared to Hprt were 3.7±1.6 times less in spleen, 10.7±1.2 times less in liver, and 21.6±3.7 times lower in brain and accordingly even lower in the tissues of the Mcph1gt/gt animals (76.9±21.1 times, 45.1±12.1 times, 46.3±3.6, respectively).
Negative_regulation (numbers) of Mcph1 in brain
7) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0 Pain Relevance 0
Using G2 phase irradiation under exactly identical conditions as described by Xu et al. (2004), flow cytometric analysis revealed a decrease of p-H3-positive Mcph1gt/gt fibroblasts by 87.2% 2 h after provision of 4 Gy.
Negative_regulation (decrease) of Mcph1gt in fibroblasts
8) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821930 Disease Relevance 0.08 Pain Relevance 0

General Comments

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