INT296169

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Creb1) endosome (Htr4) mitochondrion (Creb1)
nucleolus (Creb1) nucleus (Creb1) plasma membrane (Htr4)
Htr4 (Rattus norvegicus)
Creb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 52 100.00 Very High Very High Very High
sSRI 46 99.98 Very High Very High Very High
depression 4 96.28 Very High Very High Very High
antidepressant 25 96.00 Very High Very High Very High
fluoxetine 12 87.32 High High
Serotonin 2 50.00 Quite Low
Pyramidal cell 17 13.48 Low Low
Hippocampus 8 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 4 96.28 Very High Very High Very High
Decapitation 1 5.00 Very Low Very Low Very Low
Overdose 1 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Obviously, such impressive effects induced by the SSRI/5-HT4 agonist association on the 5-HT transmission-pCREB-behavior “continuum” strongly support its use as a bi-therapy strategy for the treatment of depression.
5-HT4 Binding (association) of pCREB associated with depression, agonist and ssri
1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2821932 Disease Relevance 0.10 Pain Relevance 0.56

General Comments

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