INT29619

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Context Info
Confidence 0.05
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.59
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FSHB) small molecule metabolic process (FSHB) extracellular region (FSHB)
cellular nitrogen compound metabolic process (FSHB) cytoplasm (FSHB)
Anatomy Link Frequency
ovary 3
Sertoli cells 2
pituitary gland 2
uterus 1
FSHB (Homo sapiens)
Pain Link Frequency Relevance Heat
opiate 2 99.28 Very High Very High Very High
antagonist 11 99.00 Very High Very High Very High
narcan 1 98.56 Very High Very High Very High
agonist 10 97.96 Very High Very High Very High
Opioid 1 89.84 High High
dexamethasone 2 34.64 Quite Low
Central nervous system 11 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Precocious Puberty 86 84.76 Quite High
Reprotox - General 3 18 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low
Reprotox - General 1 5 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Central Nervous System Cancer 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum FSH concentrations
Negative_regulation (Serum) of Gene_expression (concentrations) of FSH
1) Confidence 0.05 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Possible effects may be decreased production of GnRH by the hypothalamus (negative feedback system) and of LH and FSH by the pituitary gland.
Negative_regulation (decreased) of Gene_expression (production) of FSH in pituitary gland
2) Confidence 0.02 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0.12
Clinical studies indicate that the herb mixture could markedly reduce the blood levels of FSH, LH, E2 of the patients, and the volume of uterus and ovary as well.
Negative_regulation (reduce) of Gene_expression (levels) of FSH in ovary
3) Confidence 0.01 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.30 Pain Relevance 0.04
Clinical studies indicate that the herb mixture could markedly reduce the blood levels of FSH, LH, E2 of the patients, and the volume of uterus and ovary as well.
Negative_regulation (reduce) of in uterus Gene_expression (levels) of FSH in ovary
4) Confidence 0.00 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.30 Pain Relevance 0.04
Also, chronic beta-endorphin treatment of the Sertoli cells significantly inhibited basal and FSH-stimulated androgen-binding protein production, this effect being prevented by the universal opiate antagonist naloxone.
Negative_regulation (prevented) of Gene_expression (production) of FSH-stimulated in Sertoli cells associated with antagonist, narcan and opiate
5) Confidence 0.00 Published 1988 Journal J. Steroid Biochem. Section Abstract Doc Link 2838695 Disease Relevance 0 Pain Relevance 0.38

General Comments

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