INT296212

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.24
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transferase activity, transferring acyl groups (CLOCK) DNA binding (CLOCK) cytoplasm (CLOCK)
signal transducer activity (CLOCK) signal transduction (CLOCK) chromosome (CLOCK)
CLOCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 19 65.52 Quite High
Serotonin 3 14.08 Low Low
intrathecal 3 5.00 Very Low Very Low Very Low
Neuronal excitability 2 5.00 Very Low Very Low Very Low
Action potential 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 1 99.20 Very High Very High Very High
Disease 1 72.32 Quite High
Headache 20 65.52 Quite High
Thrombosis Related Under Development 1 5.00 Very Low Very Low Very Low
Coagulation Disorder 1 5.00 Very Low Very Low Very Low
Lumbar Puncture Related Headaches 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Depression 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mood [2] and mania-like behavior [3] have been induced by disruption of the CLOCK gene, and a food-entrainable circadian rhythm was found to be regulated by a dorsomedial hypothalamic oscillator [4].
Negative_regulation (disruption) of CLOCK gene associated with manic depressive disorder
1) Confidence 0.04 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2822736 Disease Relevance 0.24 Pain Relevance 0.07

General Comments

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