INT296220

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.99
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid metabolic process (Pla2g6) cytoplasm (Pla2g6)
Anatomy Link Frequency
monocyte 2
Pla2g6 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 4 99.96 Very High Very High Very High
Root ganglion neuron 3 99.32 Very High Very High Very High
withdrawal 96 93.56 High High
fibrosis 53 84.88 Quite High
addiction 3 83.56 Quite High
aspirin 10 76.96 Quite High
agonist 76 67.60 Quite High
Inflammation 21 47.76 Quite Low
Pain 17 25.20 Quite Low
TRP channel 6 16.56 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 13 99.00 Very High Very High Very High
Hypersensitivity 179 95.52 Very High Very High Very High
Cystic Fibrosis 35 84.88 Quite High
Sprains And Strains 9 62.56 Quite High
Bordatella Infection 4 54.88 Quite High
Pseudomonas Infection 5 50.00 Quite Low
Respiratory Sounds 1 49.92 Quite Low
Airway Obstruction 3 49.40 Quite Low
Pneumonia 7 47.76 Quite Low
Hyperplasia 4 47.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we cannot exclude the contribution of another PLA2, iPLA2, to this process.
Gene_expression (contribution) of iPLA2
1) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.16 Pain Relevance 0.12
The results of the in vivo studies with icilin and LPC agree well with our earlier in vitro studies [6] demonstrating that LPLs produced by iPLA2 play an important role in regulating the cold sensitivity of TRPM8. iPLA2 inhibition with BEL reduced the cold hypersensitivity induced by icilin, consistent with our in vitro findings that BEL inhibited TRPM8 responses to icilin.
Gene_expression (produced) of iPLA2 associated with hypersensitivity
2) Confidence 0.40 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.22 Pain Relevance 0.03
A reduction of iPLA2 expression with antisense oligonucleotides has also been shown to inhibit TRPM8 activity [34].
Gene_expression (expression) of iPLA2
3) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.34 Pain Relevance 0.15
Prior administration of the selective iPLA2 inhibitor BEL (30-300 ?
Gene_expression (selective) of iPLA2
4) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2822744 Disease Relevance 0.22 Pain Relevance 0.12
Lysophosphatidic acid is also produced in a spatially regulated fashion by the Ca2+-independent phospholipase A2 (iPLA2) at the leading edge of the migrating monocyte (Carnevale and Cathcart, 2001; Mishra et al., 2008).
Gene_expression (produced) of iPLA2 in monocyte
5) Confidence 0.17 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.05 Pain Relevance 0.04
generates arachidonic acid in the cytoplasm and localizes to the trailing edge in monocytes migrating towards MCP-1 chemokine, iPLA2 produces LPA and is localized to the pseudopods where actin polymerization is actively regulated.
Gene_expression (produces) of iPLA2 in monocytes associated with chemokine
6) Confidence 0.15 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0.05

General Comments

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