INT296253

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.71
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2ca) chromosome (Ppp2ca) plasma membrane (Ppp2ca)
cytoskeleton (Ppp2ca) nucleus (Ppp2ca) cytoplasm (Ppp2ca)
Ppp2ca (Mus musculus)
Pain Link Frequency Relevance Heat
depression 31 100.00 Very High Very High Very High
long-term potentiation 20 90.08 High High
ischemia 6 79.52 Quite High
Dopamine 20 67.80 Quite High
Hippocampus 12 67.04 Quite High
nMDA receptor 53 63.96 Quite High
alcohol 25 50.00 Quite Low
antagonist 5 50.00 Quite Low
Dynorphin 2 28.12 Quite Low
opiate 1 24.88 Low Low
Disease Link Frequency Relevance Heat
Depression 31 100.00 Very High Very High Very High
Anxiety Disorder 24 95.92 Very High Very High Very High
Targeted Disruption 41 88.36 High High
Neurodegenerative Disease 3 82.88 Quite High
Diabetes Mellitus 4 80.56 Quite High
Cv Unclassified Under Development 6 79.52 Quite High
Parkinson's Disease 20 65.28 Quite High
Hepatocellular Cancer 2 55.56 Quite High
Aging 3 50.88 Quite High
Coronary Heart Disease 8 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, expression of PP2AA was significantly downregulated by acute ethanol exposure, the effect of which was intensified by ADH.
Negative_regulation (downregulated) of Gene_expression (expression) of PP2AA
1) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0 Pain Relevance 0
Our findings in ASKO mice demonstrated that a loss of a-Syn produced the opposite effect on TH and PP2A imply that enzymatic dysregulation can also occur by a loss of soluble a-Syn, as those mice express normal levels of ?
Negative_regulation (opposite) of Gene_expression (effect) of PP2A
2) Confidence 0.38 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0.12 Pain Relevance 0.06
Our findings suggest that the phosphorylation of AMPK at Thr172 may be influenced by the expression of PP2A but less likely PP2C?
Negative_regulation (influenced) of Gene_expression (expression) of PP2A
3) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.30 Pain Relevance 0.04
In mice lacking calcineurin or with expression of small t antigen of simian virus 40 inhibiting PP2A, LTD is selectively reduced.
Negative_regulation (reduced) of Gene_expression (expression) of PP2A associated with depression
4) Confidence 0.15 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 1.30 Pain Relevance 0.51

General Comments

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