INT296275

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 3.58
Pain Relevance 5.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Dlg4, Kcnip3) plasma membrane (Dlg4, Kcnip3) transport (Kcnip3)
Golgi apparatus (Kcnip3) endoplasmic reticulum (Kcnip3) intracellular (Kcnip3)
Dlg4 (Mus musculus)
Kcnip3 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 689 99.84 Very High Very High Very High
depression 403 98.00 Very High Very High Very High
long-term potentiation 260 97.28 Very High Very High Very High
Hippocampus 156 92.36 High High
Glutamate receptor 26 88.24 High High
Dynorphin 26 86.12 High High
cytokine 13 84.12 Quite High
opiate 13 82.88 Quite High
antagonist 65 75.00 Quite High
Central nervous system 26 70.60 Quite High
Disease Link Frequency Relevance Heat
Depression 403 98.00 Very High Very High Very High
Anxiety Disorder 312 97.04 Very High Very High Very High
Targeted Disruption 273 85.44 High High
Repression 13 70.84 Quite High
Nociception 39 65.24 Quite High
Pain 39 56.60 Quite High
Shock 117 44.56 Quite Low
Leukemia 13 26.60 Quite Low
Brain Disease 13 5.00 Very Low Very Low Very Low
Drug Dependence 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, Ca2+-insensitive TgDREAM may constitutively interact with PSD-95 and inhibit NMDA receptor trafficking or there is an impaired recruitment of TgDREAM-bound PSD-95 to synaptic protein complexes needed for NMDA receptor function.
PSD-95 Binding (interact) of TgDREAM associated with nmda receptor
1) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.14 Pain Relevance 0.60
In the present study, we propose that DREAM binds with PSD95 and thus affects NMDA receptor function and the induction of LTD.
PSD95 Binding (binds) of DREAM associated with depression and nmda receptor
2) Confidence 0.34 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.84 Pain Relevance 0.90
DREAM interacts with PSD-95
PSD-95 Binding (interacts) of DREAM
3) Confidence 0.34 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.12 Pain Relevance 0.57
Co-immunoprecipitation experiments using a monoclonal antibody specific for DREAM showed that DREAM is associated with PSD-95 in hippocampal extracts from wild-type mice (Figure 6A).
PSD-95 Binding (associated) of DREAM
4) Confidence 0.34 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.44
Furthermore, the role of Ca2+ in the interaction between DREAM and PSD-95 was studied.
PSD-95 Binding (interaction) of DREAM
5) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.33
Co-immunoprecipitation results indicated that DREAM interacts with PSD-95.
PSD-95 Binding (interacts) of DREAM
6) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.45 Pain Relevance 0.16
We found that the expression of PSD-95 is not changed in TgDREAM mice, however, co-immunoprecipitation experiments show that there is a direct interaction between DREAM and PSD-95.
PSD-95 Binding (interaction) of DREAM
7) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.17 Pain Relevance 0.68
The interaction between DREAM and PSD-95 was shown by coimmunoprecipitation from hippocampal tissue, homogenized and lysed by in buffer: Tris pH 7.5, 50 mM; NaCl 150 mM; NP40 1%; Na-deoxycholate 0.25%; protease inhibitor cocktail.
PSD-95 Binding (interaction) of DREAM
8) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.12
Future studies are needed to explore the molecular mechanisms underlying the interaction between DREAM and PSD95 and how this interaction affects NMDA receptor function.


PSD95 Binding (interaction) of DREAM associated with nmda receptor
9) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.47 Pain Relevance 0.59
The interaction between DREAM and PSD-95 was shown by coimmunoprecipitation from hippocampal tissue, homogenized and lysed by in buffer: Tris pH 7.5, 50 mM; NaCl 150 mM; NP40 1%; Na-deoxycholate 0.25%; protease inhibitor cocktail.
PSD-95 Binding (interaction) of DREAM
10) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.12
Biochemical experiments found that DREAM interacts with PSD-95 and may inhibit NMDA receptor function through this interaction.
PSD-95 Binding (interacts) of DREAM associated with nmda receptor
11) Confidence 0.29 Published 2010 Journal Mol Brain Section Abstract Doc Link PMC2822766 Disease Relevance 0.60 Pain Relevance 0.46
Taken together, these data indicate there is a specific interaction between DREAM and PSD-95, and Ca2+ negatively regulates the interaction.
PSD-95 Binding (interaction) of DREAM
12) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.26
We showed that there is impaired LTD in TgDREAM mice, which may be due, at least in part, to a reduced function of NMDA receptor by the interaction between DREAM and PSD-95 (Figure 9).
PSD-95 Binding (interaction) of DREAM associated with depression and nmda receptor
13) Confidence 0.29 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.79 Pain Relevance 0.37

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