INT296277

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.09
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Car2, Kcnip3) cytosol (Car2, Kcnip3) transport (Kcnip3)
lyase activity (Car2) Golgi apparatus (Kcnip3) endoplasmic reticulum (Kcnip3)
Anatomy Link Frequency
nucleus 2
neurons 1
Car2 (Mus musculus)
Kcnip3 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 212 99.00 Very High Very High Very High
depression 128 98.48 Very High Very High Very High
spinal dorsal horn 4 96.56 Very High Very High Very High
Central grey 4 95.76 Very High Very High Very High
Hippocampus 50 95.04 Very High Very High Very High
Thalamus 4 94.92 High High
Somatosensory cortex 4 92.96 High High
Anterior cingulate cortex 4 92.08 High High
Pain 5 83.20 Quite High
potassium channel 9 80.48 Quite High
Disease Link Frequency Relevance Heat
Depression 128 98.48 Very High Very High Very High
Urological Neuroanatomy 4 95.76 Very High Very High Very High
Targeted Disruption 88 88.92 High High
Pain 13 83.20 Quite High
Anxiety Disorder 96 70.64 Quite High
Brain Disease 4 51.48 Quite High
Drug Dependence 4 49.56 Quite Low
Repression 4 35.96 Quite Low
Helminth Infection 1 34.52 Quite Low
Congenital Anomalies 1 19.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, Ca2+-insensitive TgDREAM may constitutively interact with PSD-95 and inhibit NMDA receptor trafficking or there is an impaired recruitment of TgDREAM-bound PSD-95 to synaptic protein complexes needed for NMDA receptor function.
Ca2 Binding (interact) of TgDREAM associated with nmda receptor
1) Confidence 0.18 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.19 Pain Relevance 0.65
The DREAM was characterized as a multifunctional Ca2+ binding protein with defined functions both in and outside the nucleus.
Ca2 Binding (protein) of DREAM in nucleus
2) Confidence 0.18 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.15 Pain Relevance 0.23
As a multifunctional Ca2+-binding protein highly expressed in neurons, DREAM is an attractive candidate serving critical roles in brain functions.
Ca2 Binding (binding) of DREAM in neurons
3) Confidence 0.17 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.33 Pain Relevance 0.50
Furthermore, the role of Ca2+ in the interaction between DREAM and PSD-95 was studied.
Ca2 Binding (interaction) of DREAM
4) Confidence 0.17 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0 Pain Relevance 0.35
DREAM can act in the nucleus by binding in a Ca2+-dependent manner to a specific DNA sequence and may control aspects of synaptic plasticity through changes in gene expression.
Ca2 Binding (binding) of DREAM in nucleus
5) Confidence 0.07 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948346 Disease Relevance 0.42 Pain Relevance 0.32

General Comments

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