INT296287

Context Info Confidence 0.27 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.31 Pain Relevance 0.27

nucleus (Camk4, Creb1) mitochondrion (Creb1) DNA binding (Creb1) cytoplasm (Camk4) signal transduction (Camk4) nucleocytoplasmic transport (Camk4)

Anatomy Link Frequency nucleus 2 Camk4 (Mus musculus) Creb1 (Mus musculus)

Pain Link Frequency Relevance Heat long-term potentiation 20 90.80 Neurotransmitter 1 67.76 Lasting pain 2 62.80 drug abuse 1 62.24 Central nervous system 2 55.84 potassium channel 2 52.96 depression 31 50.00 antagonist 5 50.00 nMDA receptor 53 49.36 Hippocampus 12 5.00

Disease Link Frequency Relevance Heat Brain Disease 1 64.16 Anxiety Disorder 24 63.16 Pain 3 62.80 Drug Dependence 1 62.24 Depression 31 50.00 Targeted Disruption 21 20.16 Shock 9 5.00 Nociception 3 5.00 Repression 1 5.00 Urological Neuroanatomy 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both PKA and CaMKIV regulate the activation of CREB in the nucleus either through the subunit translocation (in case of PKA) or the entry of CaM (CaMKIV) [28-30].

CaMKIV Regulation (regulate) of Positive_regulation (activation) of CREB in nucleus

1) Confidence 0.27 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.31 Pain Relevance 0.27

General Comments

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