INT296319

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Context Info
Confidence 0.40
First Reported 2010
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.84
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pou5f1) nucleoplasm (Pou5f1) nucleus (Pou5f1)
DNA binding (Pou5f1) transcription factor binding (Pou5f1) cytoplasm (Pou5f1)
Pou5f1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 1 99.28 Very High Very High Very High
Inflammatory mediators 1 76.52 Quite High
Central nervous system 24 5.00 Very Low Very Low Very Low
neurotrophin 3 24 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 144 99.82 Very High Very High Very High
Cytomegalovirus Infection 168 99.62 Very High Very High Very High
INFLAMMATION 2 76.12 Quite High
Tendinopathy 6 74.72 Quite High
Viral Infection 39 59.36 Quite High
Obesity 9 59.32 Quite High
Cancer 7 56.40 Quite High
Calcification 4 54.96 Quite High
Neurodegenerative Disease 18 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We then went on to determine if MCMV infection had any effect on Oct4 expression among this defined subset of cells.
Regulation (effect) of Gene_expression (expression) of Oct4 associated with cytomegalovirus infection and infection
1) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.38 Pain Relevance 0
Oct4 expression must be closely regulated; too much or too little will actually induce differentiation [26].
Regulation (regulated) of Gene_expression (expression) of Oct4
2) Confidence 0.40 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.06 Pain Relevance 0
Altered expression of the Oct4 transcription factor
Regulation (Altered) of Gene_expression (expression) of Oct4
3) Confidence 0.30 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.07 Pain Relevance 0
Like previous studies that showed Oct-4 expression in human and mouse BMSCs [23-25], we also found that TSCs expressed Oct-4, encouraging future examination of whether the multi-potency of TSCs demonstrated in this study depends on Oct-4 expression.
Spec (whether) Regulation (depends) of Gene_expression (expression) of Oct-4 associated with potency
4) Confidence 0.09 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2822826 Disease Relevance 0.32 Pain Relevance 0.09

General Comments

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