INT29635

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Context Info
Confidence 0.76
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 6.05
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Eno2) plasma membrane (Eno2) intracellular (Eno2)
cytoplasm (Eno2)
Anatomy Link Frequency
neuron 4
neuronal 2
nerve 1
epidermis 1
tubules 1
Eno2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 6 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
ischemia 62 98.92 Very High Very High Very High
anesthesia 3 97.76 Very High Very High Very High
Pain 3 91.24 High High
Chronic pancreatitis 1 89.12 High High
Lamotrigine 90 86.60 High High
cva 4 81.04 Quite High
Glutamate 8 67.44 Quite High
sodium channel 2 42.36 Quite Low
Disease Link Frequency Relevance Heat
Pheochromocytoma 6 99.12 Very High Very High Very High
Cancer 54 99.08 Very High Very High Very High
Cv Unclassified Under Development 60 98.92 Very High Very High Very High
Islet Cell Adenoma 4 98.32 Very High Very High Very High
Granular Cell Tumor 10 98.00 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 1 97.12 Very High Very High Very High
Asphyxia 4 94.68 High High
Neurofibromatosis 6 94.48 High High
Hypoglycemia 3 93.44 High High
Metastasis 10 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuron-specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase), was adopted as one of important quantitative index in our study, because it was reported that NSE is released into the cerebral spinal fluid (CSF) and systemic circulation when neuronal damage has occurred (Schoerkhuber et al 1990; Martens et al 1998; Wang et al 1999; Verdu et al 2001), and NSE is highly specific to the neuron.


Localization (released) of NSE in neuronal
1) Confidence 0.76 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.39 Pain Relevance 0.30
Cytoplasm granules are typically seen under light microscopy, and the cells are positive for S100 immunoperoxidase and neuron-specific enolase.
Localization (immunoperoxidase) of neuron-specific enolase in neuron
2) Confidence 0.74 Published 2008 Journal Brazilian journal of otorhinolaryngology Section Abstract Doc Link 19082363 Disease Relevance 1.37 Pain Relevance 0.09
Neuron-specific enolase (NSE), an isoenzyme of the glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase), was adopted as one of important quantitative index in our study, because it was reported that NSE is released into the cerebral spinal fluid (CSF) and systemic circulation when neuronal damage has occurred (Schoerkhuber et al 1990; Martens et al 1998; Wang et al 1999; Verdu et al 2001), and NSE is highly specific to the neuron.


Localization (released) of NSE in neuronal
3) Confidence 0.71 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721363 Disease Relevance 0.41 Pain Relevance 0.36
Neuron-specific enolase was localized in nerve fibers, normal islet cells, and islet cell tumors; its concentration was elevated only in the tissue of islet cell tumors and in serum from patients with insulinoma.
Localization (localized) of Neuron-specific enolase in nerve associated with hypoglycemia and islet cell adenoma
4) Confidence 0.63 Published 1986 Journal Gastroenterology Section Abstract Doc Link 3015709 Disease Relevance 0.94 Pain Relevance 0.09
Immunohistochemical localization of neuron-specific enolase (NSE) was seen in all tumors and in the four normal adrenals.
Localization (localization) of neuron-specific enolase in neuron associated with cancer
5) Confidence 0.27 Published 1984 Journal Arch. Pathol. Lab. Med. Section Abstract Doc Link 6203498 Disease Relevance 1.29 Pain Relevance 0.09
[Diagnostic value of s-100 protein and neuron-specific enolase as serum markers for cerebral deficiency after general anesthesia.
Localization (value) of neuron-specific enolase in neuron associated with anesthesia
6) Confidence 0.16 Published 2000 Journal Anaesthesist Section Title Doc Link 11100253 Disease Relevance 0.09 Pain Relevance 0.10
Antibodies to S-100 protein, calretinin, vimentin, neuron-specific enolase (NSE), and Ki-67 (MIB-1) were obtained from DakoCytomation (Kyoto, Japan).
Localization (calretinin) of neuron-specific enolase in neuron
7) Confidence 0.04 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2954971 Disease Relevance 0.22 Pain Relevance 0
Formalin-fixed and paraffin-embedded pancreatic tissue was used as a positive control for synaptophysin, chromogranin, and neuron-specific enolase (NSE); hepatic tissue for alpha-fetoprotein (AFP) and Hep-Par1; and epidermis for cytokeratin.
Localization (tissue) of neuron-specific enolase in epidermis
8) Confidence 0.02 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1950516 Disease Relevance 0.40 Pain Relevance 0.07
The pancreatic and jejunal tumors showed all structural and secretory patterns of epithelial endocrine tumors, including expression of cytokeratin, neuroendocrine markers like neuron-specific enolase, chromogranins and synaptophysin, peptides like VIP, PHM, GRH, PP, insulin, neurotensin, glucagon, somatostatin and enkephalin, secretory granules, small clear vesicles, peculiar osmiophilic bodies, and occasional formation of tubules or microacini with specialized luminal surfaces.
Localization (secretory) of neuron-specific enolase in tubules associated with cancer, somatostatin and enkephalin
9) Confidence 0.02 Published 1988 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2839087 Disease Relevance 0.94 Pain Relevance 0.26

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