INT29637

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Context Info
Confidence 0.20
First Reported 1988
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.55
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KRT1) cytoskeleton (KRT1)
Anatomy Link Frequency
tubules 1
KRT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 100.00 Very High Very High Very High
Somatostatin 2 100.00 Very High Very High Very High
Paracetamol 2 73.40 Quite High
Neuropeptide 1 25.00 Low Low
antagonist 3 7.76 Low Low
psoriasis 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 97 99.48 Very High Very High Very High
Adamantinoma 80 98.40 Very High Very High Very High
Synovial Sarcoma 1 97.56 Very High Very High Very High
Chordoma 1 96.84 Very High Very High Very High
Sarcoma 1 95.88 Very High Very High Very High
Shock 2 94.48 High High
Metastasis 11 94.24 High High
Cleidocranial Dysplasia 98 93.48 High High
Syndrome 1 91.20 High High
Vipoma 1 90.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that k1/k2 decreases from expiration to inspiration in normals indicates that phasic activity of UA dilators stabilizes the UA.
Localization (decreases) of k1
1) Confidence 0.20 Published 2005 Journal Respir Res Section Body Doc Link PMC1236961 Disease Relevance 0.18 Pain Relevance 0
Three days post NAC exposure, differentiation of NHEK is demonstrated by an increased number of intercellular junctions, basal localization of cytokeratin and apical localization of actin determined by scanning electron micrographs of cells and sub-structures and high resolution confocal fluorescence immuno micrographs of for example ?
Localization (localization) of cytokeratin
2) Confidence 0.06 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.56 Pain Relevance 0.07
Three days post NAC exposure, differentiation of NHEK is demonstrated by an increased number of intercellular junctions, basal localization of cytokeratin and apical localization of actin determined by scanning electron micrographs of cells and sub-structures and high resolution confocal fluorescence immuno micrographs of for example ?
Localization (localization) of cytokeratin
3) Confidence 0.06 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.56 Pain Relevance 0.07
According to a study on the antibodies against a subtype of cytokeratin by Hazelbag et al, cytokeratin (CK) in AD is different from synovial sarcoma, chordoma, or epithelial sarcoma.13 Benassi et al. insisted on a correlation between OFD and AD based on their results that showed positive CK19 and negative CK8 and CK18 staining in both OFD and AD cases.12 In a cytogenetic study, both OFD and AD have trisomies on chromosomes 7, 8, and 12.4,16
Localization (subtype) of cytokeratin associated with sarcoma, adamantinoma, cleidocranial dysplasia, synovial sarcoma, generaliased trisomy and chordoma
4) Confidence 0.04 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628088 Disease Relevance 3.19 Pain Relevance 0
Immunostaining with anti-cytokeratin of WalBC cells grown in culture showed 90% of cells exhibited strong cytokeratin immunoreactivity which localized to the cytoplamic region of positive cells (Fig. 3D).
Localization (localized) of cytokeratin
5) Confidence 0.02 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.12 Pain Relevance 0
The pancreatic and jejunal tumors showed all structural and secretory patterns of epithelial endocrine tumors, including expression of cytokeratin, neuroendocrine markers like neuron-specific enolase, chromogranins and synaptophysin, peptides like VIP, PHM, GRH, PP, insulin, neurotensin, glucagon, somatostatin and enkephalin, secretory granules, small clear vesicles, peculiar osmiophilic bodies, and occasional formation of tubules or microacini with specialized luminal surfaces.
Localization (secretory) of cytokeratin in tubules associated with cancer, somatostatin and enkephalin
6) Confidence 0.01 Published 1988 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 2839087 Disease Relevance 0.95 Pain Relevance 0.26

General Comments

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