INT296440

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.14
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gria1) transport (Gria1) endoplasmic reticulum (Gria1)
plasma membrane (Gria1) protein complex (Gria1)
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn neuron 6 93.96 High High
Inflammation 9 90.76 High High
Hyperalgesia 4 88.88 High High
IPN 9 70.84 Quite High
Kinase C 18 69.92 Quite High
Visceral pain 1 60.96 Quite High
Hippocampus 7 48.12 Quite Low
central sensitization 9 43.04 Quite Low
Spinal cord 10 40.72 Quite Low
spinal dorsal horn 7 19.76 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 90.76 High High
Hyperalgesia 5 88.88 High High
Nociception 26 86.36 High High
Targeted Disruption 1 71.56 Quite High
Inflammatory Pain 9 70.84 Quite High
Injury 2 62.16 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

1 60.96 Quite High
Disease 1 27.36 Quite Low
Neurodegenerative Disease 1 11.60 Low Low
Motor Neuron Diseases 1 8.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rapid alterations in the composition of synaptic AMPA receptors induced by physiologic activity or noxious stimuli can be achieved by modulating the phosphorylation status of GluR1 and GluR2 subunits and their binding to PDZ domain-containing synaptic scaffolding proteins.
Regulation (modulating) of GluR1 Binding (binding) of
1) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 1.08 Pain Relevance 0.66

General Comments

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