INT296442

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2, GRIP1, Gria2) plasma membrane (Gria2, GRIP1, Gria2) transport (Gria2, Gria2)
protein complex (Gria2, Gria2) cytosol (GRIP1) cytoplasmic membrane-bounded vesicle (GRIP1)
Gria2 (Mus musculus)
GRIP1 (Homo sapiens)
Gria2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 18 96.88 Very High Very High Very High
Dorsal horn neuron 6 95.04 Very High Very High Very High
Inflammation 9 92.16 High High
Glutamate receptor 11 67.36 Quite High
Lasting pain 6 58.72 Quite High
Neuropathic pain 4 53.48 Quite High
IPN 9 52.48 Quite High
Hippocampus 7 30.04 Quite Low
central sensitization 9 27.32 Quite Low
Spinal cord 10 22.40 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 92.16 High High
Hypersensitivity 2 75.28 Quite High
Nociception 26 71.84 Quite High
Pain 8 58.72 Quite High
Neuropathic Pain 4 53.48 Quite High
Inflammatory Pain 9 52.48 Quite High
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, the disruption of GluR2 binding to its synaptic anchoring protein (GRIP) can result in a switch of GluR2-containing AMPA receptors to GluR2-lacking AMPA receptors.
GluR2 Binding (binding) of GRIP Positive_regulation (result) of Negative_regulation (switch) of AMPA
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.45 Pain Relevance 0.53

General Comments

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