INT296457

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a, Gria1) cytosol (Gria1) transport (Gria1)
endoplasmic reticulum (Gria1) protein complex (Gria1) kinase activity (Camk2a)
Camk2a (Mus musculus)
Gria1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 7 94.36 High High
central sensitization 9 91.64 High High
Spinal cord 10 86.72 High High
IPN 9 72.40 Quite High
Kinase C 18 70.32 Quite High
Neuropathic pain 4 70.32 Quite High
Lasting pain 6 59.76 Quite High
Glutamate receptor 11 42.72 Quite Low
Pain 10 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 26 77.08 Quite High
Inflammatory Pain 9 72.40 Quite High
Neuropathic Pain 4 70.32 Quite High
Pain 8 58.88 Quite High
INFLAMMATION 9 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaMKII may indirectly mediate the phosphorylation of GluR1 at the Serine845 site through adenylate cyclase and PKA, since the Ca2+-calmodulin complex can stimulate adenylate cyclase, and subsequently activate more cAMP production and PKA activity.
CaMKII Spec (may) Positive_regulation (mediate) of Phosphorylation (phosphorylation) of GluR1
1) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.28 Pain Relevance 0.49

General Comments

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