INT296458

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.86
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Gria2, Pick1) plasma membrane (Gria2, Pick1) mitochondrion (Pick1)
transport (Gria2) Golgi apparatus (Pick1) endoplasmic reticulum (Gria2)
Gria2 (Mus musculus)
Pick1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 23 99.40 Very High Very High Very High
Hyperalgesia 8 92.96 High High
Inflammation 18 92.44 High High
spinal dorsal horn 14 85.32 High High
Pain 21 82.80 Quite High
Multiple sclerosis 1 80.60 Quite High
ischemia 1 79.48 Quite High
Kinase C 37 75.04 Quite High
IPN 18 67.52 Quite High
Central nervous system 17 65.52 Quite High
Disease Link Frequency Relevance Heat
Nociception 52 97.60 Very High Very High Very High
Hyperalgesia 10 92.96 High High
INFLAMMATION 18 92.44 High High
Disease 6 85.68 High High
Pain 17 82.80 Quite High
Convulsion 1 82.20 Quite High
Demyelinating Disease 1 80.60 Quite High
Cv Unclassified Under Development 1 79.48 Quite High
Neurological Disease 1 78.72 Quite High
Male Infertility 1 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PICK1 has also been found to bind to the C-terminal of GluR2, -3, -4 subunits of AMPA receptors through the PDZ domain [44].
AMPA Binding (bind) of PICK1
1) Confidence 0.24 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.57 Pain Relevance 0.37
PICK1 has also been found to bind to the C-terminal of GluR2, -3, -4 subunits of AMPA receptors through the PDZ domain [44].
GluR2 Binding (bind) of PICK1
2) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.57 Pain Relevance 0.37
For example, interaction of PICK1 with GluR2, an AMPA-type glutamate receptor subunit, is important for synaptic targeting and surface expression of AMPA receptors during synaptic plasticity [26-33].
GluR2 Binding (interaction) of PICK1 associated with glutamate receptor
3) Confidence 0.08 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.72 Pain Relevance 0.33

General Comments

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