INT296460

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.49
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gria2) endoplasmic reticulum (Gria2) cytoskeleton (Myo18a)
plasma membrane (Gria2) protein complex (Gria2) cytoplasm (Myo18a)
Gria2 (Mus musculus)
Myo18a (Mus musculus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 21 98.00 Very High Very High Very High
Hyperalgesia 12 91.80 High High
Inflammation 27 91.28 High High
Neuropathic pain 12 87.92 High High
Kinase C 54 80.96 Quite High
Spinal cord 30 75.28 Quite High
IPN 27 66.36 Quite High
Dorsal horn neuron 18 30.08 Quite Low
nMDA receptor 12 17.36 Low Low
central sensitization 27 5.20 Low Low
Disease Link Frequency Relevance Heat
Nociception 78 96.44 Very High Very High Very High
Hyperalgesia 15 91.80 High High
INFLAMMATION 27 91.28 High High
Neuropathic Pain 12 87.92 High High
Inflammatory Pain 27 66.36 Quite High
Hypersensitivity 6 37.00 Quite Low
Pain 24 5.00 Very Low Very Low Very Low
Depression 6 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PICK1 has also been found to bind to the C-terminal of GluR2, -3, -4 subunits of AMPA receptors through the PDZ domain [44].
AMPA Binding (bind) of PDZ
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.56 Pain Relevance 0.36
PICK1 has also been found to bind to the C-terminal of GluR2, -3, -4 subunits of AMPA receptors through the PDZ domain [44].
GluR2 Binding (bind) of PDZ
2) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.56 Pain Relevance 0.36
Other critical PDZ-domain-containing proteins, such as GRIP and ABP were found to interact with the xS/TxV motif at the extreme C-terminal of short forms of AMPA receptor subunits [43,50].
AMPA receptor Binding (interact) of PDZ
3) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.36 Pain Relevance 0.33

General Comments

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