INT296465

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.05
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) structural molecule activity (Dlg4)
nucleus (Rbm39) plasma membrane (Dlg4) protein complex assembly (Dlg4)
Anatomy Link Frequency
spinal 1
tail 1
Dlg4 (Mus musculus)
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 100.00 Very High Very High Very High
Spinal sensitization 2 98.76 Very High Very High Very High
central sensitization 18 96.60 Very High Very High Very High
Kinase C 36 72.92 Quite High
Hyperalgesia 8 49.88 Quite Low
Inflammation 18 49.36 Quite Low
spinal dorsal horn 14 42.24 Quite Low
IPN 18 24.44 Low Low
Neuropathic pain 8 10.76 Low Low
Glutamate receptor 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 52 54.52 Quite High
Hyperalgesia 10 49.88 Quite Low
INFLAMMATION 18 49.36 Quite Low
Inflammatory Pain 18 24.44 Low Low
Neuropathic Pain 8 10.76 Low Low
Pain 16 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it may suggest that the Stargazin-mediated interaction of AMPA receptors with PSD-95 is possibly implicated in the spinal sensitization.
PSD-95 Binding (interaction) of receptors in spinal associated with spinal sensitization
1) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.17
Binding of the C-terminal tail of Stargazin to PDZ domains of a number of synaptic scaffolding proteins, such as PSD-95 (an interacting protein associated with NR2 subunits of the NMDA receptors) may mediate the synaptic targeting of surface AMPA receptors [56].
PSD-95 Binding (associated) of receptors in tail associated with nmda receptor
2) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.05 Pain Relevance 0.17

General Comments

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