INT296475

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.63
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Pick1, Myo18a) mitochondrion (Pick1) Golgi apparatus (Pick1)
enzyme binding (Pick1) protein complex (Pick1) protein targeting (Pick1)
Pick1 (Mus musculus)
Myo18a (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 4 92.96 High High
Inflammation 9 92.44 High High
ASIC 33 88.20 High High
spinal dorsal horn 7 85.32 High High
Kinase C 21 77.12 Quite High
IPN 9 67.52 Quite High
Dopamine 6 59.00 Quite High
Neuropathic pain 4 53.84 Quite High
nMDA receptor 7 17.36 Low Low
Spinal cord 10 16.24 Low Low
Disease Link Frequency Relevance Heat
Nociception 26 97.60 Very High Very High Very High
Hyperalgesia 5 92.96 High High
INFLAMMATION 9 92.44 High High
Toxicity 18 84.36 Quite High
Targeted Disruption 4 81.08 Quite High
Disease 13 71.84 Quite High
Brain Injury 3 71.04 Quite High
Inflammatory Pain 9 67.52 Quite High
Acidosis 12 63.44 Quite High
Death 24 61.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PICK1 has also been found to bind to the C-terminal of GluR2, -3, -4 subunits of AMPA receptors through the PDZ domain [44].
PICK1 Binding (bind) of PDZ
1) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.57 Pain Relevance 0.37
While the detailed mechanisms need more clarification, these findings suggest that PICK1 is a common protein trafficking regulator that couples membrane proteins to trafficking machinery via its unique combination of the PDZ domain and BAR domain.


PICK1 Binding (combination) of PDZ
2) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.08 Pain Relevance 0.03
Consistent with earlier results [38,39], a direct interaction between PICK1 and ASIC1a through the PDZ interaction is important.
PICK1 Binding (interaction) of PDZ
3) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.49 Pain Relevance 0.09
Consistent with earlier results [38,39], a direct interaction between PICK1 and ASIC1a through the PDZ interaction is important.
PICK1 Binding (interaction) of PDZ
4) Confidence 0.00 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0.49 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox