INT296477

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.22
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacng2) structural molecule activity (Dlg4) plasma membrane (Dlg4)
protein complex assembly (Dlg4) neurological system process (Cacng2) cytoplasm (Dlg4)
Anatomy Link Frequency
spinal 1
tail 1
Cacng2 (Mus musculus)
Dlg4 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal sensitization 2 98.76 Very High Very High Very High
nMDA receptor 8 97.56 Very High Very High Very High
central sensitization 18 97.36 Very High Very High Very High
Kinase C 36 77.44 Quite High
Hyperalgesia 8 54.40 Quite High
Inflammation 18 53.88 Quite High
spinal dorsal horn 14 46.76 Quite Low
IPN 18 28.96 Quite Low
Neuropathic pain 8 15.28 Low Low
Glutamate receptor 22 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 52 59.04 Quite High
Hyperalgesia 10 54.40 Quite High
INFLAMMATION 18 53.88 Quite High
Inflammatory Pain 18 28.96 Quite Low
Neuropathic Pain 8 15.28 Low Low
Pain 16 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it may suggest that the Stargazin-mediated interaction of AMPA receptors with PSD-95 is possibly implicated in the spinal sensitization.
Stargazin Binding (interaction) of PSD-95 in spinal associated with spinal sensitization
1) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0 Pain Relevance 0.17
Binding of the C-terminal tail of Stargazin to PDZ domains of a number of synaptic scaffolding proteins, such as PSD-95 (an interacting protein associated with NR2 subunits of the NMDA receptors) may mediate the synaptic targeting of surface AMPA receptors [56].
Stargazin Binding (Binding) of PSD-95 in tail associated with nmda receptor
2) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.22 Pain Relevance 0.24

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox