INT296479

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.55
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GRIP1) endoplasmic reticulum (GRIP1) cytoplasmic membrane-bounded vesicle (GRIP1)
plasma membrane (GRIP1) intracellular (GRIP1)
GRIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 36 99.74 Very High Very High Very High
Pain 20 96.84 Very High Very High Very High
Dorsal horn neuron 12 94.24 High High
Inflammation 18 91.28 High High
Lasting pain 12 85.68 High High
central sensitization 18 80.80 Quite High
Spinal cord 20 78.48 Quite High
Neuropathic pain 8 72.24 Quite High
Hyperalgesia 8 69.68 Quite High
spinal dorsal horn 14 60.64 Quite High
Disease Link Frequency Relevance Heat
Nociception 52 95.00 High High
INFLAMMATION 18 91.28 High High
Pain 16 85.68 High High
Neuropathic Pain 8 72.24 Quite High
Hyperalgesia 10 69.68 Quite High
Motor Neuron Diseases 2 66.60 Quite High
Disease 2 65.12 Quite High
Neurodegenerative Disease 2 65.04 Quite High
Targeted Disruption 2 52.36 Quite High
Inflammatory Pain 18 51.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The phosphorylation of GluR2 subunit at Serine880 by PKC may lead to disrupt the interaction between GluR2 and GRIP and follow by GluR2 internalization.
Negative_regulation (disrupt) of GRIP Binding (interaction) of associated with kinase c
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.60 Pain Relevance 0.50
It subsequently disrupted the binding of GluR2 subunits to synaptic anchoring protein (GRIP) and result in a switch of GluR2-containing AMPA receptors to GluR2-lacking AMPA receptors.
Negative_regulation (disrupted) of GRIP Binding (binding) of
2) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.95 Pain Relevance 0.68

General Comments

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