INT296484

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 4.52
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Gria2, GRIP1) plasma membrane (Gria2, GRIP1) cytosol (GRIP1)
transport (Gria2) cytoplasmic membrane-bounded vesicle (GRIP1) intracellular (GRIP1)
Anatomy Link Frequency
neurons 1
synapses 1
Gria2 (Mus musculus)
GRIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate receptor 110 100.00 Very High Very High Very High
Kinase C 180 99.74 Very High Very High Very High
Hyperalgesia 40 98.92 Very High Very High Very High
Inflammation 90 98.40 Very High Very High Very High
Neuropathic pain 40 96.52 Very High Very High Very High
Pain 100 96.36 Very High Very High Very High
Lasting pain 60 95.08 Very High Very High Very High
Dorsal horn neuron 60 95.04 Very High Very High Very High
spinal dorsal horn 70 91.28 High High
IPN 90 88.84 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 50 98.92 Very High Very High Very High
INFLAMMATION 90 98.40 Very High Very High Very High
Nociception 260 98.24 Very High Very High Very High
Neuropathic Pain 40 96.52 Very High Very High Very High
Pain 80 95.08 Very High Very High Very High
Inflammatory Pain 90 88.84 High High
Hypersensitivity 20 71.36 Quite High
Motor Neuron Diseases 10 66.12 Quite High
Disease 10 65.12 Quite High
Neurodegenerative Disease 10 64.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This phosphorylation of GluR2 on Serine880 may further impede the affinity of GluR2 for GRIP, release GluR2 from GRIP-GluR2 complex and finally lead to the internalization of GluR2 subunits.
GluR2 Binding (affinity) of GRIP
1) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.34 Pain Relevance 0.21
Taken together, the interaction between GluR2 and GRIP in spinal neurons might be involved in the nociceptive regulation through affecting the internalization of GluR2.
GluR2 Spec (might) Binding (interaction) of GRIP in neurons associated with nociception
2) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.61 Pain Relevance 0.39
The interference of the interaction between GluR2 and GRIP by GluR2 phosphorylation apparently disrupts AMPA receptor GluR2 clusters [45].
GluR2 Binding (interaction) of GRIP
3) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.30 Pain Relevance 0.54
The interaction of GluR2 and GRIP plays a significant role in clustering AMPA receptors at spinal excitatory synapses in a model of neuropathic pain [13].
GluR2 Binding (interaction) of GRIP in synapses associated with neuropathic pain
4) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.35 Pain Relevance 0.31
The phosphorylation of GluR2 subunit at Serine880 by PKC may lead to disrupt the interaction between GluR2 and GRIP and follow by GluR2 internalization.
GluR2 Binding (interaction) of GRIP associated with kinase c
5) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.60 Pain Relevance 0.50
Subsequently, the disruption of GluR2 binding to its synaptic anchoring protein (GRIP) can result in a switch of GluR2-containing AMPA receptors to GluR2-lacking AMPA receptors.
GluR2 Binding (binding) of GRIP
6) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.40 Pain Relevance 0.53
The interference of the interaction between GluR2 and GRIP by GluR2 phosphorylation apparently disrupts AMPA receptor GluR2 clusters [45].
GluR2 Binding (interaction) of GRIP
7) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.30 Pain Relevance 0.54
It has been found that phosphorylation of GluR2 at Serine880 by PKC reduces the affinity of GluR2 for GRIP, thus, released GluR2 from GRIP and promotes the internalization of GluR2 [36].
GluR2 Binding (affinity) of GRIP associated with kinase c
8) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.36 Pain Relevance 0.30
AMPA receptor GluR2 subunit may bind to cellular partner proteins, such as glutamate receptor interacting protein (GRIP) and this signal protein interacting with C-Kinase (PICK1), which plays an important role in the synaptic GluR2 trafficking [43,44].
AMPA receptor GluR2 subunit Binding (bind) of GRIP associated with glutamate receptor
9) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.33 Pain Relevance 0.60
It subsequently disrupted the binding of GluR2 subunits to synaptic anchoring protein (GRIP) and result in a switch of GluR2-containing AMPA receptors to GluR2-lacking AMPA receptors.
GluR2 Binding (binding) of GRIP
10) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC2823608 Disease Relevance 0.95 Pain Relevance 0.67

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