INT296618

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.42
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) DNA binding (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Smad2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 18 50.80 Quite High
fibrosis 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ureteral Obstruction 50 99.64 Very High Very High Very High
Stress 24 99.40 Very High Very High Very High
Fibrosis 40 95.68 Very High Very High Very High
Shock 4 75.08 Quite High
Injury 12 58.16 Quite High
INFLAMMATION 16 50.80 Quite High
Pulmonary Fibrosis 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Renal Disease 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies demonstrated that nuclear p-smad2 was significantly increased after UUO and that juglone prevented nuclear p-smad2 activity.
Negative_regulation (prevented) of p-smad2 associated with ureteral obstruction
1) Confidence 0.37 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.50 Pain Relevance 0
The antifibrotic effects of juglone may result from the inhibition of smad2 and oxidative stress.



Negative_regulation (inhibition) of smad2 associated with stress
2) Confidence 0.31 Published 2010 Journal Fibrogenesis Tissue Repair Section Abstract Doc Link PMC2823698 Disease Relevance 0.92 Pain Relevance 0.03

General Comments

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