INT296623

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.88
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) Golgi apparatus (Cdh1) plasma membrane (Cdh1)
cytoplasm (Cdh1)
Anatomy Link Frequency
plasma 1
stellate cells 1
kidney 1
Cdh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 9 62.76 Quite High
cytokine 3 52.92 Quite High
fibrosis 6 49.92 Quite Low
chemokine 1 48.08 Quite Low
anesthesia 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 20 98.60 Very High Very High Very High
Coronary Artery Disease 36 98.40 Very High Very High Very High
Stress 12 94.08 High High
Ureteral Obstruction 25 92.32 High High
Injury 6 89.72 High High
Disease 1 86.60 High High
Heat Stress Disorders 1 82.80 Quite High
Targeted Disruption 4 71.12 Quite High
INFLAMMATION 8 62.76 Quite High
Internal Fibrosis 1 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that E-cadherin derived from a transferred gene can be transported to the plasma membrane in hormone-producing cells.
Positive_regulation (derived) of E-cadherin in plasma
1) Confidence 0.35 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.45 Pain Relevance 0
These results are not sufficient to confirm that E-cadherin was successfully induced in hormone-producing cells, because rE-cad-IZ transfection of non-hormone-producing folliculo-stellate cells, which express both E- and N-cadherin [8], may yield similar results.
Positive_regulation (induced) of E-cadherin in stellate cells associated with coronary artery disease
2) Confidence 0.35 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875860 Disease Relevance 0.33 Pain Relevance 0
We recently demonstrated that specific inhibitors of Nox (the primary generator of superoxide anion in the kidney) decreased fibrogenesis in kidney allografts by decreasing fibronectin and phospho-smad2 and increasing E-cadherin levels [7].
Positive_regulation (increasing) of E-cadherin in kidney associated with fibrosis
3) Confidence 0.15 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 1.09 Pain Relevance 0.09

General Comments

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