INT296659

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.54
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cds1) nucleotidyltransferase activity (Cds1)
Cds1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 147 100.00 Very High Very High Very High
antagonist 6 97.88 Very High Very High Very High
Serotonin 78 96.04 Very High Very High Very High
depression 18 93.44 High High
agonist 6 77.20 Quite High
monoamine 42 50.00 Quite Low
fluoxetine 27 5.00 Very Low Very Low Very Low
sSRI 12 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
tricyclic antidepressant 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 18 93.44 High High
Cognitive Disorder 3 85.36 High High
Congenital Anomalies 6 84.56 Quite High
Urological Neuroanatomy 21 71.36 Quite High
Lipidosis 6 26.92 Quite Low
Toxicity 6 5.44 Low Low
Aids-related Complex 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This prompted the need to investigate the effects of the drugs on CDP-diacylglycerol synthase activity.
Spec (investigate) Regulation (effects) of CDP-diacylglycerol
1) Confidence 0.41 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2823756 Disease Relevance 0.30 Pain Relevance 0.19
These observations suggest that the drug effects on CDP-diacylglycerol and phosphatidylinositide synthesis involve a mechanism that may not depend on increased synaptic serotonin action.
Regulation (effects) of CDP-diacylglycerol associated with serotonin
2) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2823756 Disease Relevance 0.14 Pain Relevance 0.45
The present study was directed at testing the hypothesis that the nucleolipid effects of antidepressants on CDP-diacylglycerol and its derived inositol phospholipids are substantially independent of the known effects of the drugs to enhance synaptic serotonin levels.
Regulation (effects) of CDP-diacylglycerol associated with antidepressant and serotonin
3) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2823756 Disease Relevance 0.09 Pain Relevance 0.44

General Comments

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