INT29667

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Context Info
Confidence 0.54
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.09
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CRHR1) signal transducer activity (CRHR1)
Anatomy Link Frequency
pituitary 2
neurons 1
amygdala 1
CRHR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
amygdala 3 98.92 Very High Very High Very High
alcohol 273 97.88 Very High Very High Very High
GABAergic 6 96.76 Very High Very High Very High
depression 81 96.52 Very High Very High Very High
gABA 6 92.48 High High
Serotonin 13 90.24 High High
opioid receptor 1 86.32 High High
Neurotransmitter 6 86.12 High High
Opioid 3 85.52 High High
imagery 9 77.88 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 2 97.08 Very High Very High Very High
Depression 93 96.52 Very High Very High Very High
Chronic Renal Failure 2 81.40 Quite High
Syndrome 5 80.32 Quite High
Growth Hormone Deficiency 7 76.32 Quite High
Suicidal Behaviour 367 75.24 Quite High
Hypopituitarism 1 75.00 Quite High
Dyspepsia 1 61.84 Quite High
Pain 23 60.80 Quite High
Disease 13 54.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that CRF activates one fifth of the myenteric neurons, via CRF1 receptor activation.
Positive_regulation (activation) of CRF1 in neurons
1) Confidence 0.54 Published 2008 Journal Verh. K. Acad. Geneeskd. Belg. Section Abstract Doc Link 18630723 Disease Relevance 0.12 Pain Relevance 0.19
Preliminary GTPgamma35S binding studies to CRF1 coupled G-protein indicated an antagonistic action for hypericin.
Positive_regulation (coupled) of CRF1
2) Confidence 0.44 Published 2001 Journal Pharmacopsychiatry Section Abstract Doc Link 11518063 Disease Relevance 0 Pain Relevance 0.39
The activation of corticotropin-releasing factor type 1 (CRF1) receptors in the central amygdala appear to be crucial for the potentiation of GABAergic activity [128].
Positive_regulation (activation) of CRF1 in amygdala associated with gabaergic and amygdala
3) Confidence 0.34 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872355 Disease Relevance 0.15 Pain Relevance 0.61
With a qPCR candidate gene approach, they observed an upregulation of genes activating the hypothalamus-pituitary-adrenal axis (including the corticotropin-releasing hormone and its receptor [CRHR1] and NR3C2 encoding the mineralocorticoid receptor) and downregulation of inhibiting genes (eg, androgen receptor).
Positive_regulation (upregulation) of CRHR1 in pituitary
4) Confidence 0.28 Published 2010 Journal Curr Psychiatry Rep Section Body Doc Link PMC2847693 Disease Relevance 0.36 Pain Relevance 0.31
In particular, a large proportion of the patients who require r-hGH therapy are children, so an r-hGH administration device must be child-friendly.
Positive_regulation (require) of r-hGH
5) Confidence 0.08 Published 2006 Journal BMC Endocr Disord Section Body Doc Link PMC1618831 Disease Relevance 0.29 Pain Relevance 0
According to their corticotropin-releasing factor-corticotropin-cortisol (CAC) axis function as evaluated by basal plasma cortisol levels and the response of cortisol to insulin hypoglycemia and to corticotropin-releasing factor, the patients were divided into three groups: group 1 (n = 25), patients with multiple hypothalamic and/or pituitary hormone deficiencies with normal CAC axis; group 2 (n = 38), patients with partial CAC deficiency without cortisol replacement therapy (hydrocortisone); and group 3 (n = 9), patients with CAC deficiency receiving hydrocortisone therapy (5 to 10 mg/d).
Positive_regulation (evaluated) of corticotropin-releasing factor-corticotropin-cortisol in pituitary associated with hypoglycemia
6) Confidence 0.06 Published 1988 Journal Am. J. Dis. Child. Section Abstract Doc Link 2839978 Disease Relevance 0.17 Pain Relevance 0

General Comments

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