INT29668

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 5.52
Pain Relevance 4.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTGER1) signal transducer activity (PTGER1)
Anatomy Link Frequency
HT-29 1
corpus 1
PGE1 1
structural cells 1
PTGER1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 105 99.84 Very High Very High Very High
Codeine 7 99.20 Very High Very High Very High
Neuropathic pain 27 99.16 Very High Very High Very High
aspirin 19 99.06 Very High Very High Very High
lidocaine 5 98.70 Very High Very High Very High
Analgesic 6 98.64 Very High Very High Very High
cINOD 16 97.28 Very High Very High Very High
Stimulus evoked pain 6 96.76 Very High Very High Very High
Pain 55 96.52 Very High Very High Very High
Inflammatory stimuli 6 91.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 136 99.84 Very High Very High Very High
Disease 30 99.68 Very High Very High Very High
Neuropathic Pain 45 99.16 Very High Very High Very High
Hypersensitivity 16 96.76 Very High Very High Very High
Pain 40 96.52 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

3 96.08 Very High Very High Very High
Asthma 14 94.36 High High
Neuroma 36 94.12 High High
Rheumatoid Arthritis 2 93.76 High High
Wallerian Degeneration 3 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of EP1 receptors in injured sensory neurones and inflammatory cells deserves further investigation.
Regulation (regulation) of EP1 associated with inflammation
1) Confidence 0.45 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.67 Pain Relevance 0.55
Pharmacological manipulation of EP receptor isoforms confirms a role for EP3/cAMP signalling in PGE2-dependent HT-29 cell proliferation
Regulation (manipulation) of EP receptor in HT-29
2) Confidence 0.26 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2615781 Disease Relevance 0.08 Pain Relevance 0.21
A number of clinical and animal model pharmacological studies suggest that Cox-2 and EP1 are key therapeutic targets in inflammatory and neuropathic pain.
Regulation (targets) of EP1 associated with inflammation and neuropathic pain
3) Confidence 0.20 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 1.45 Pain Relevance 1.14
The emerging general consensus of animal and human studies identifies the EP1 receptor as a selective target of therapeutic value, of similar analgesic effect as non-steroidal anti-inflammatory drugs (NSAIDs), but with fewer potential side effects [18].
Regulation (target) of EP1 associated with inflammation, analgesic and cinod
4) Confidence 0.20 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.97 Pain Relevance 1.16
However, this is in contradiction with our results where EP1 and EP3 are down- regulated in the disease groups.
Regulation (regulated) of EP1 associated with disease
5) Confidence 0.12 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 1.23 Pain Relevance 0.30
More recently, a study comparing EP receptor expression in nasal biopsies from aspirin intolerant and tolerant patients showed an up-regulation of EP1 and EP2 in structural cells from aspirin intolerant subjects [15].
Regulation (regulation) of EP1 in structural cells associated with aspirin
6) Confidence 0.12 Published 2006 Journal Respir Res Section Body Doc Link PMC1481584 Disease Relevance 0.72 Pain Relevance 0.34
Lidocaine (0.1 mmol/l) and codeine (1.0 mmol/l) similarly potentiated the effect of the adenylate cyclase stimulator prostaglandin E1 (PGE1).
Regulation (effect) of PGE1 associated with lidocaine and codeine
7) Confidence 0.04 Published 1988 Journal Arzneimittelforschung Section Abstract Doc Link 2840087 Disease Relevance 0 Pain Relevance 0.68
Mucosal PGE(2) was unchanged in all regions; transcript levels of both cyclo-oxygenases/5-lipoxygenase were unaffected (except for a trend of increasing cyclo-oxygenase-2 in the corpus).
Neg (unchanged) Regulation (unchanged) of PGE in corpus
8) Confidence 0.02 Published 2006 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 16393293 Disease Relevance 0 Pain Relevance 0
With respect to stimulatory receptor systems, a reciprocal regulation was observed for prostaglandin E1 (PGE1) receptors and Gs alpha, the G protein subunit activating adenylate cyclase.
Regulation (regulation) of PGE1 in PGE1
9) Confidence 0.01 Published 1994 Journal J. Neurochem. Section Abstract Doc Link 8133263 Disease Relevance 0.30 Pain Relevance 0.12

General Comments

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