INT296685

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.18
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
myoblasts 1
neurons 1
20S (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 2 16.44 Low Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Glutamate receptor 16 5.00 Very Low Very Low Very Low
tetrodotoxin 10 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
depression 5 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Action potential 4 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 4 99.26 Very High Very High Very High
Multiple Sclerosis 87 78.96 Quite High
Disease 26 50.00 Quite Low
Myotonic Dystrophy 22 50.00 Quite Low
Targeted Disruption 21 38.44 Quite Low
Aging 10 30.64 Quite Low
Toxicity 16 5.00 Very Low Very Low Very Low
Myotonia 14 5.00 Very Low Very Low Very Low
Congenital Anomalies 11 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it has been shown that the 20S proteasome is inhibited by CCUG repeats in DM2 myoblasts increasing stability of proteins [52].
Negative_regulation (inhibited) of 20S in myoblasts
1) Confidence 0.57 Published 2010 Journal Current Genomics Section Body Doc Link PMC2874224 Disease Relevance 0 Pain Relevance 0
Moreover, when 20S proteasomes were inhibited by MG132 (final concentration of 5 ┬ÁM) no substrate degradation was observed, confirming the absence of other proteases in the 20S proteasome preparation.
Negative_regulation (inhibited) of 20S
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2823778 Disease Relevance 0.08 Pain Relevance 0
It is also noteworthy that we could not detect by mass spectrometry parkin (an E3 mutated in autosomal-recessive juvenile Parkinsonism) and PI31 (which may function as an inhibitor of the 20S proteasome), which have been reported to interact with proteasomes in non-neuronal cells (McCutchen-Maloney et al., 2000; Sakata et al., 2003).
Negative_regulation (inhibitor) of 20S in neuronal associated with parkinson's disease
3) Confidence 0.42 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.10 Pain Relevance 0
In the NMDA-treated neurons, about a third of the 26S particles and up to 50% of the free 19S were lost in four hours without any concomitant loss of the 20S particle.
Negative_regulation (loss) of 20S in neurons
4) Confidence 0.42 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0

General Comments

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