INT29671

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Context Info
Confidence 0.24
First Reported 1988
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 1.04
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Anatomy Link Frequency
cortex 2
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 145 100.00 Very High Very High Very High
antagonist 32 100.00 Very High Very High Very High
opioid receptor 26 100.00 Very High Very High Very High
narcan 24 100.00 Very High Very High Very High
gABA 4 99.20 Very High Very High Very High
opiate 5 98.44 Very High Very High Very High
Morphine 12 98.04 Very High Very High Very High
Pain 57 95.12 Very High Very High Very High
GABAergic 2 89.80 High High
IPN 38 88.32 High High
Disease Link Frequency Relevance Heat
Pain 59 95.12 Very High Very High Very High
Nociception 48 93.32 High High
Inflammatory Pain 38 88.32 High High
Drug Dependence 1 87.84 High High
INFLAMMATION 76 79.72 Quite High
Post Operative Pain 4 73.20 Quite High
Hemorrhage 1 64.88 Quite High
Necrosis 4 32.20 Quite Low
Cancer 4 31.84 Quite Low
Targeted Disruption 2 26.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The autoradiographic technique was used to visualise neuroanatomical changes in opioid receptor occupancy, probably reflecting changes in opioid peptide release, as a result of social activity.
Regulation (changes) of Localization (release) of opioid peptide associated with opioid receptor and opioid
1) Confidence 0.24 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350555 Disease Relevance 0 Pain Relevance 0.92
The effect of the opioid receptor antagonist naloxone on pulsatile LH secretion was evaluated in 1-, 2-, and 8-week orchidectomized (ORDX) rats.
Regulation (effect) of Localization (secretion) of opioid receptor associated with antagonist, narcan and opioid receptor
2) Confidence 0.08 Published 1988 Journal Endocrinology Section Abstract Doc Link 2840268 Disease Relevance 0.06 Pain Relevance 0.40
The aim of the current study was to examine whether there were changes in the localization and density of micro-opioid receptor subtype (MOR1) and GABA in the visual cortex of morphine-dependent and abstinent rats.
Spec (whether) Regulation (changes) of Localization (localization) of micro-opioid receptor in cortex associated with gaba, opioid receptor and morphine
3) Confidence 0.08 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17950530 Disease Relevance 0 Pain Relevance 0.69
We next identified the molecular mechanisms responsible for tonic opioid peptide release.
Regulation (responsible) of Localization (release) of opioid peptide associated with opioid
4) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.54 Pain Relevance 1.03
Furthermore, opioid peptide release was dependent on intracellular calcium mobilisation as well as PI3K activation (Fig. 6F–H).
Regulation (dependent) of Localization (release) of opioid peptide associated with opioid
5) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.25 Pain Relevance 0.64
Phe27Cys polymorphism alters the maturation and subcellular localization of the human delta opioid receptor.
Regulation (alters) of Localization (localization) of opioid receptor associated with opioid receptor
6) Confidence 0.01 Published 2009 Journal Traffic Section Title Doc Link 19000170 Disease Relevance 0.18 Pain Relevance 0.24

General Comments

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