INT29671

Context Info Confidence 0.24 First Reported 1988 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 4 Total Number 6 Disease Relevance 1.04 Pain Relevance 3.92

plasma membrane (Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Anatomy Link Frequency cortex 2 Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Opioid 145 100.00 antagonist 32 100.00 opioid receptor 26 100.00 narcan 24 100.00 gABA 4 99.20 opiate 5 98.44 Morphine 12 98.04 Pain 57 95.12 GABAergic 2 89.80 IPN 38 88.32

Disease Link Frequency Relevance Heat Pain 59 95.12 Nociception 48 93.32 Inflammatory Pain 38 88.32 Drug Dependence 1 87.84 INFLAMMATION 76 79.72 Post Operative Pain 4 73.20 Hemorrhage 1 64.88 Necrosis 4 32.20 Cancer 4 31.84 Targeted Disruption 2 26.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The autoradiographic technique was used to visualise neuroanatomical changes in opioid receptor occupancy, probably reflecting changes in opioid peptide release, as a result of social activity.

Regulation (changes) of Localization (release) of opioid peptide associated with opioid receptor and opioid

1) Confidence 0.24 Published 1999 Journal Brain Res. Section Abstract Doc Link 10350555 Disease Relevance 0 Pain Relevance 0.92

The effect of the opioid receptor antagonist naloxone on pulsatile LH secretion was evaluated in 1-, 2-, and 8-week orchidectomized (ORDX) rats.

Regulation (effect) of Localization (secretion) of opioid receptor associated with antagonist, narcan and opioid receptor

2) Confidence 0.08 Published 1988 Journal Endocrinology Section Abstract Doc Link 2840268 Disease Relevance 0.06 Pain Relevance 0.40

The aim of the current study was to examine whether there were changes in the localization and density of micro-opioid receptor subtype (MOR1) and GABA in the visual cortex of morphine-dependent and abstinent rats.

Spec (whether) Regulation (changes) of Localization (localization) of micro-opioid receptor in cortex associated with gaba, opioid receptor and morphine

3) Confidence 0.08 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17950530 Disease Relevance 0 Pain Relevance 0.69

We next identified the molecular mechanisms responsible for tonic opioid peptide release.

Regulation (responsible) of Localization (release) of opioid peptide associated with opioid

4) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.54 Pain Relevance 1.03

Furthermore, opioid peptide release was dependent on intracellular calcium mobilisation as well as PI3K activation (Fig. 6F–H).

Regulation (dependent) of Localization (release) of opioid peptide associated with opioid

5) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.25 Pain Relevance 0.64

Phe27Cys polymorphism alters the maturation and subcellular localization of the human delta opioid receptor.

Regulation (alters) of Localization (localization) of opioid receptor associated with opioid receptor

6) Confidence 0.01 Published 2009 Journal Traffic Section Title Doc Link 19000170 Disease Relevance 0.18 Pain Relevance 0.24

General Comments

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