INT29674

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 4.59
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) aging (Ada)
cell adhesion (Ada) plasma membrane (Ada) lysosome (Ada)
Anatomy Link Frequency
pleural fluid 2
skeletal muscles 2
spinal nerve 1
spinal 1
neurons 1
Ada (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 85 100.00 Very High Very High Very High
antinociception 2 99.96 Very High Very High Very High
allodynia 6 99.12 Very High Very High Very High
Morphine 9 97.52 Very High Very High Very High
tetrodotoxin 8 97.16 Very High Very High Very High
antagonist 6 93.92 High High
palliative 1 93.48 High High
Spinal nerve ligature 3 93.04 High High
Opioid 3 88.00 High High
abdominal pain 1 86.48 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 155 100.00 Very High Very High Very High
Pressure And Volume Under Development 2 100.00 Very High Very High Very High
Malignant Pleural Effusion 9 99.28 Very High Very High Very High
Adhesions 5 99.22 Very High Very High Very High
Neuropathic Pain 9 99.12 Very High Very High Very High
Toxicity 4 98.38 Very High Very High Very High
Pleural Effusion 22 98.12 Very High Very High Very High
Tuberculous Peritonitis 3 94.96 High High
Abdominal Pain 1 86.48 High High
Hyperalgesia 2 86.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of the ADA and XO genes in those tissues returned to the control level during morphine withdrawal, with the exception of the skeletal muscles; and (v) the upregulation of the expression of the ADA and XO genes induced by morphine treatment could be reversed by naloxone.
Gene_expression (expression) of ADA in skeletal muscles
1) Confidence 0.78 Published 2007 Journal Acta Pharmacol. Sin. Section Body Doc Link 17640470 Disease Relevance 0 Pain Relevance 0
The expression of the ADA and XO genes in those tissues returned to the control level during morphine withdrawal, with the exception of the skeletal muscles; and (v) the upregulation of the expression of the ADA and XO genes induced by morphine treatment could be reversed by naloxone.
Gene_expression (expression) of ADA in skeletal muscles
2) Confidence 0.78 Published 2007 Journal Acta Pharmacol. Sin. Section Body Doc Link 17640470 Disease Relevance 0 Pain Relevance 0
In contrast, spinal injection of adenosine deaminase or reuptake inhibitors greatly enhanced the effect of spinal morphine, resulting in over 80% reversal of allodynia.
Gene_expression (injection) of adenosine deaminase in spinal associated with adenocard, allodynia and morphine
3) Confidence 0.68 Published 1999 Journal Pain Section Abstract Doc Link 10204715 Disease Relevance 0.75 Pain Relevance 2.07
The aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats.
Gene_expression (activities) of adenosine deaminase associated with toxicity and adenocard
4) Confidence 0.67 Published 2003 Journal Toxicology Section Abstract Doc Link 12965118 Disease Relevance 0.10 Pain Relevance 0.17
The aim of this experimental study was to investigate the effects of erdosteine, an antioxidant agent, on doxorubicin (DXR)-induced cardio-toxicity through nitric oxide (NO) levels, collagen synthesis, xanthine oxidase (XO) and adenosine deaminase (ADA) activities in rats.
Gene_expression (activities) of ADA associated with toxicity and adenocard
5) Confidence 0.67 Published 2003 Journal Toxicology Section Abstract Doc Link 12965118 Disease Relevance 0.10 Pain Relevance 0.17
Cyclic AMP was elevated in rat jejunal mucosa in the presence of adenosine deaminase (2 mg/1) both alone or under conditions of stimulated mucosal cyclic AMP accumulation (forskolin 20 microM/papaverine 100 microM).
Gene_expression (presence) of adenosine deaminase associated with adenocard
6) Confidence 0.66 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2840297 Disease Relevance 0 Pain Relevance 0.35
Similarly, there is no evidence for up-regulation in spinal A1 adenosine receptors after spinal nerve ligation, and the adenosine deaminase experiment is consistent with a depletion of adenosine in spinal cord tissue after spinal nerve ligation.


Gene_expression (experiment) of adenosine deaminase in spinal nerve
7) Confidence 0.64 Published 2002 Journal Anesthesiology Section Body Doc Link 11753009 Disease Relevance 0 Pain Relevance 0
The levels of ascites adenosine deaminase are also useful for diagnosis.
Gene_expression (levels) of adenosine deaminase associated with pressure and volume under development and adenocard
8) Confidence 0.58 Published 1998 Journal Nippon Rinsho Section Abstract Doc Link 9883620 Disease Relevance 0.91 Pain Relevance 0.14
2 = 0.44, df = 1, p = 0.51) and significant for the ADA factor (?
Gene_expression (factor) of ADA associated with anxiety disorder
9) Confidence 0.40 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2289811 Disease Relevance 0.66 Pain Relevance 0
Both 1,3-dipropyl-8-cyclopentylxanthine and the adenosine-degrading enzyme adenosine deaminase produced an apparently irreversible depolarization of the membrane potential by about 20 mV.
Gene_expression (produced) of adenosine deaminase associated with adenocard
10) Confidence 0.35 Published 1993 Journal Neuroscience Section Abstract Doc Link 8309525 Disease Relevance 0 Pain Relevance 0.39
Details of the process will be forthcoming from ADA sources in the near future.
Gene_expression (sources) of ADA
11) Confidence 0.25 Published 2002 Journal Tex Dent J Section Abstract Doc Link 11922015 Disease Relevance 0.07 Pain Relevance 0.21
Also, the etiology was corroborated with the levels of Adenosine deaminase (ADA) in pleural fluid and results analyzed.


Gene_expression (levels) of Adenosine deaminase in pleural fluid associated with adenocard
12) Confidence 0.15 Published 2010 Journal Lung India : Official Organ of Indian Chest Society Section Body Doc Link PMC2988168 Disease Relevance 0.64 Pain Relevance 0.09
To determine whether the increased metabolism of ATP and the resultant increase in adenosine release were responsible for inhibition of neutrophil adhesion to endothelium, we determined whether addition of adenosine deaminase (ADA, 0.125 IU/ml), an enzyme that converts extracellular adenosine to its inactive metabolite, inosine, affected inhibition of neutrophil adhesion to endothelium by stimulated neutrophils.
Gene_expression (addition) of adenosine deaminase in neutrophils associated with adenocard and adhesions
13) Confidence 0.10 Published 1994 Journal Inflammation Section Abstract Doc Link 8088928 Disease Relevance 0.52 Pain Relevance 0.41
Inhibitors of adenosine kinase, but not adenosine deaminase, produce antinociception when administered spinally.
Gene_expression (produce) of adenosine deaminase associated with antinociception and adenocard
14) Confidence 0.09 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8832217 Disease Relevance 0 Pain Relevance 0.66
Increased pleural fluid adenosine deaminase levels in patients with malignant pleural effusions: a potential predictor of talc pleurodesis outcome.
Gene_expression (levels) of pleural fluid adenosine deaminase in pleural fluid associated with adenocard and malignant pleural effusion
15) Confidence 0.01 Published 2007 Journal Lung Section Title Doc Link 17952507 Disease Relevance 0.83 Pain Relevance 0.18
Further, both 8-(p-sulphophenyl)theophylline and adenosine deaminase reduced the effect of the myenteric plexus on striatal neurons in the absence of tetrodotoxin, and the adenylate cyclase activator forskolin completely reversed the effect of tetrodotoxin in our co-culture system.
Gene_expression (reduced) of adenosine deaminase in neurons associated with tetrodotoxin and adenocard
16) Confidence 0.01 Published 1996 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8884377 Disease Relevance 0 Pain Relevance 0.86

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