INT296753

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.73 Pain Relevance 0.07

cell differentiation (Scrib) cell proliferation (Scrib) plasma membrane (Scrib) cytoplasm (Scrib)

Anatomy Link Frequency epithelium 1 Scrib (Mus musculus)

Pain Link Frequency Relevance Heat Bioavailability 1 74.16 agonist 16 59.44 cINOD 7 21.04 Inflammation 3 5.00 COX-2 inhibitor 2 5.00 corticosteroid 1 5.00 sSRI 1 5.00 fibrosis 1 5.00

Disease Link Frequency Relevance Heat Colorectal Cancer 36 100.00 Colon Cancer 1 95.76 Cancer 14 23.16 INFLAMMATION 4 5.00 Apoptosis 1 5.00 Death 1 5.00 Hemorrhagic Diathesis 1 5.00 Disease 1 5.00 Obesity 1 5.00 Cystic Fibrosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, the combined effects of increased synthesis and export together with reduced elimination and degradation of extracellular PGE2 in CRC point to a maintained higher level of PGE2 in the auto-/paracrine milieu in the CRC colonic epithelium, Figure 1.

Protein_catabolism (degradation) of CRC in epithelium associated with colorectal cancer

1) Confidence 0.05 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2824707 Disease Relevance 0.73 Pain Relevance 0.07

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