INT296765

Context Info Confidence 0.23 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.17 Pain Relevance 0.28

mRNA processing (RBFOX3) RNA binding (RBFOX3) nucleus (RBFOX3) intracellular (RBFOX3) DNA binding (RBFOX3) cytoplasm (RBFOX3)

Anatomy Link Frequency DA neurons 1 RBFOX3 (Homo sapiens)

Pain Link Frequency Relevance Heat Substantia nigra 40 93.16 imagery 45 79.16 midbrain 23 70.64 Dopamine 3 5.00 Eae 2 5.00 ketamine 1 5.00 anesthesia 1 5.00 alcohol 1 5.00 analgesia 1 5.00 gABA 1 5.00

Disease Link Frequency Relevance Heat Death 4 100.00 Toxicity 4 67.92 Hypertrophy 6 21.52 Disease 34 5.00 Parkinson's Disease 8 5.00 Frailty 4 5.00 Disease Progression 4 5.00 Supranuclear Palsy 3 5.00 Multiple System Atrophy 3 5.00 Neurodegenerative Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This was mirrored by an 82.2 ± 2.0% reduction in NeuN-positive (+) cells (10,380 ± 934 vs. 1825 ± 236; p < 0.001; Figure 5B), strongly suggesting cell death of A9 DA neurons rather than down-regulation of TH expression in atrophic neurons.

Regulation (regulation) of NeuN in DA neurons associated with death

1) Confidence 0.23 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2824797 Disease Relevance 0.17 Pain Relevance 0.28

General Comments

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