INT296767

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.11
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (ST13) protein folding (ST13) cytosol (ST13)
protein binding, bridging (ST13) protein complex (ST13) cytoplasm (ST13)
Anatomy Link Frequency
dopaminergic neurons 1
ST13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Ventral tegmentum 14 91.12 High High
midbrain 26 86.40 High High
Dopamine 73 79.72 Quite High
imagery 46 72.16 Quite High
cocaine 7 63.40 Quite High
addiction 7 61.80 Quite High
gABA 1 60.24 Quite High
alcohol 4 24.16 Low Low
Substantia nigra 41 5.00 Very Low Very Low Very Low
Nucleus accumbens 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 4 59.16 Quite High
Disease 43 53.24 Quite High
Hypertrophy 6 36.48 Quite Low
Toxicity 4 19.04 Low Low
Drug Dependence 4 15.00 Low Low
Recurrence 1 6.68 Low Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Frailty 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent work by Matsumoto and Hikosaka challenges this model by asserting that stimuli associated with either rewarding or aversive outcomes increase the activity of dopaminergic neurons in the SNc [76].
Positive_regulation (increase) of SNc in dopaminergic neurons
1) Confidence 0.05 Published 2010 Journal Int Arch Med Section Body Doc Link PMC2958859 Disease Relevance 0.11 Pain Relevance 0.31
In support of this, densitometry analysis exposed a significant increase in iron accumulation in the ipsilateral SNc of lactacystin lesioned animals compared to saline controls (Figure 8C).
Positive_regulation (increase) of SNc
2) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2824797 Disease Relevance 0 Pain Relevance 0.17

General Comments

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