INT296769

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.12
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (ST13) protein folding (ST13) cytosol (ST13)
protein binding, bridging (ST13) protein complex (ST13) cytoplasm (ST13)
Anatomy Link Frequency
forelimb 1
basal ganglia 1
ST13 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 106 99.74 Very High Very High Very High
agonist 24 89.64 High High
gABA 25 82.20 Quite High
Substantia nigra 46 81.60 Quite High
dopamine receptor 29 78.08 Quite High
imagery 45 69.44 Quite High
antagonist 11 56.56 Quite High
Glutamate 4 53.08 Quite High
midbrain 25 52.56 Quite High
Eae 3 50.16 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 1 62.24 Quite High
Hypertrophy 6 60.84 Quite High
Frailty 4 32.88 Quite Low
Disease 56 32.00 Quite Low
Parkinson's Disease 29 5.00 Very Low Very Low Very Low
Toxicity 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Disease Progression 4 5.00 Very Low Very Low Very Low
Supranuclear Palsy 3 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of NeuN+ cells in the ipsilateral SNc also strongly correlated with both apomorphine rotations (r = -.882; p < 0.01) and forelimb grip strength (r = .829; p < 0.05).
Negative_regulation (number) of SNc in forelimb
1) Confidence 0.01 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2824797 Disease Relevance 0.06 Pain Relevance 0.21
There is also limited evidence that dendritic dopamine release may inhibit SNc neuron activity, and may, thus, indirectly affect dopamine release in the striatum, presumably resulting in secondary effect on the basal ganglia via direct and indirect pathways (Lacey et al., 1987; Pucak and Grace, 1994).


Negative_regulation (inhibit) of SNc in basal ganglia associated with dopamine
2) Confidence 0.00 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.06 Pain Relevance 0.45

General Comments

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