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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.29
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tlr9, Tlr3) endoplasmic reticulum (Tlr9, Tlr3) intracellular (Tlr9, Tlr3)
cytoplasm (Tlr9, Tlr3) signal transduction (Tlr9, Tlr3) RNA binding (Tlr3)
Tlr9 (Mus musculus)
Tlr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 75 94.96 High High
Opioid 18 73.60 Quite High
Inflammatory response 7 70.80 Quite High
cytokine 21 55.48 Quite High
Morphine 60 51.92 Quite High
opiate 1 33.68 Quite Low
Pain 2 28.04 Quite Low
rheumatoid arthritis 7 5.00 Very Low Very Low Very Low
Multiple sclerosis 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 79 94.96 High High
Syndrome 1 88.16 High High
Apoptosis 39 85.28 High High
Mycobacterial Infection 45 82.00 Quite High
Shock 4 71.48 Quite High
Infection 37 67.08 Quite High
Death 1 35.20 Quite Low
Pain 2 28.04 Quite Low
Disease 36 16.00 Low Low
Atherosclerosis 3 9.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLRs recognize distinct molecular structures on microbes, and in several cases (e.g., recognition of viruses by TLR3, TLR7, TLR8, and TLR9), different sets of TLRs have been associated with the response to different classes of microorganisms [10]–[13].
TLR9 Binding (recognition) of TLR3
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.02 Pain Relevance 0.39
Self-nucleic acids have also been described as endogenous danger signals, namely, mRNA recognised by TLR3 [29], single-stranded RNA (ssRNA) sensed by TLR7 and 8 [30], and IgG-chromatin complexes recognised by TLR9 [31].
TLR9 Binding (recognised) of TLR3
2) Confidence 0.10 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 0.27 Pain Relevance 0.06

General Comments

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